Description

3-Quinolinecarboxylic Acid, 8-Chloro-6,7-Difluoro-1-[(2R)-2-Fluorocyclopropyl]-1,4-Dihydro-4-Oxo- is a high-purity, advanced pharmaceutical intermediate characterized by its complex, multi-halogenated quinolinecarboxylic acid structure. This compound is of critical importance in the synthesis of next-generation antibacterial agents, particularly fluoroquinolone antibiotics, where its specific stereochemistry and fluorine substitutions are essential for biological activity and potency. It is primarily needed by pharmaceutical R&D laboratories, contract manufacturing organizations (CMOs), and API producers engaged in the development of novel anti-infective therapies.

Application

• Key Intermediate for Fluoroquinolone Antibiotics: Serves as a critical building block in the synthesis of advanced, broad-spectrum antibacterial agents.
• Pharmaceutical Research & Development: Used in medicinal chemistry for structure-activity relationship (SAR) studies and the development of new anti-infective drug candidates.
• Active Pharmaceutical Ingredient (API) Synthesis: Incorporated into the final chemical steps for producing target API molecules with enhanced efficacy.
• Process Chemistry & Scale-Up: Employed in optimizing synthetic routes from laboratory to pilot and commercial manufacturing scales.
• Reference Standard: Used as a high-purity analytical standard for quality control and regulatory submissions in drug development.

Basic Information

Product Name	3-Quinolinecarboxylic Acid, 8-Chloro-6,7-Difluoro-1-[(2R)-2-Fluorocyclopropyl]-1,4-Dihydro-4-Oxo-
CAS No.	1229623-10-2
Molecular Formula	C13H7ClF3NO3
Molecular Weight	329.65 g/mol
Synonyms	8-Chloro-6,7-difluoro-1-[(2R)-2-fluorocyclopropyl]-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid; (R)-8-Chloro-6,7-difluoro-1-(2-fluorocyclopropyl)-4-oxo-1,4-dihydroquinoline-3-carboxylic acid; 1-(2R)-2-Fluorocyclopropyl-8-chloro-6,7-difluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic Acid; Advanced Fluoroquinolone Intermediate; Antibacterial API Intermediate
EINECS	Contact for details

Quality Control

Our 3-Quinolinecarboxylic Acid derivative is manufactured under strict quality systems suitable for pharmaceutical applications. Each batch undergoes rigorous analytical testing, including HPLC for purity and chiral purity, and spectroscopic identification (IR, NMR), to ensure compliance with stringent internal specifications. A comprehensive Certificate of Analysis (COA) detailing all test results is provided with every shipment to support your quality and regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). The compound may be light-sensitive and should be handled accordingly to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Assay (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% (R-isomer)
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 1.0%
Residual Solvents (GC)	Meets ICH Q3C guidelines
Heavy Metals	< 20 ppm
Loss on Drying	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.