Description

2,2,2-Trifluoro-1-(3-Chloro-Phenyl)-Ethylamine Hydrochloride is a high-purity, halogenated amine salt of significant interest in advanced organic synthesis. This compound matters as a critical chiral building block and intermediate for the development of novel active pharmaceutical ingredients (APIs) and agrochemicals. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries seeking to introduce trifluoromethyl and aromatic chloro functionalities into complex molecular architectures.

Application

• Pharmaceutical Intermediate: Serves as a key chiral synthon in the research and synthesis of potential drug candidates, particularly in central nervous system (CNS) and metabolic disorder therapeutics.
• Agrochemical Synthesis: Used in the development of advanced herbicides, fungicides, and insecticides where the trifluoromethyl group enhances biological activity and environmental stability.
• Ligand and Catalyst Preparation: Acts as a precursor for chiral ligands and catalysts used in asymmetric synthesis, enabling the production of enantiomerically pure compounds.
• Material Science Research: Employed in the synthesis of specialty monomers and polymers with unique optical or electronic properties.
• Chemical Biology Probes: Utilized in the design and synthesis of molecular probes for studying enzyme mechanisms and biological pathways.
• Custom Synthesis & Contract Manufacturing: A vital starting material for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) serving global clients.

Basic Information

Item	Detail
Product Name	2,2,2-Trifluoro-1-(3-Chloro-Phenyl)-Ethylamine Hydrochloride
CAS No.	1228879-10-4
Molecular Formula	C8H8ClF3N·HCl
Molecular Weight	250.51 g/mol
Synonyms	(R/S)-1-(3-Chlorophenyl)-2,2,2-trifluoroethylamine hydrochloride; α-(Trifluoromethyl)-3-chlorobenzeneethanamine hydrochloride; 1-(3-Chlorophenyl)-2,2,2-trifluoroethan-1-amine hydrochloride; 3-Chloro-α-(trifluoromethyl)benzylamine hydrochloride; (3-Chlorophenyl)(trifluoromethyl)methylamine hydrochloride; 2,2,2-Trifluoro-1-(3-chlorophenyl)ethanamine hydrochloride
EINECS	Contact for details

Quality Control

Our 2,2,2-Trifluoro-1-(3-Chloro-Phenyl)-Ethylamine Hydrochloride is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC, NMR, and chiral purity analysis, to ensure it meets the stringent requirements for advanced synthetic applications. Certificates of Analysis (COA) with full traceability are provided and available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to exclude moisture. Keep away from incompatible materials such as strong bases and strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee (or as specified)
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.