Description

2-(1-Aminocyclobut-1-Yl)Anisole Hydrochloride, also known as 1-Amino-1-(2-Methoxyphenyl)Cyclobutane Hydrochloride, is a high-purity, advanced pharmaceutical intermediate featuring a unique cyclobutane-aniline core structure. This compound is valued for its role as a critical building block in the synthesis of novel active pharmaceutical ingredients (APIs), particularly in therapeutic areas requiring complex molecular architectures. It is primarily sought after by research institutions, contract development and manufacturing organizations (CDMOs), and pharmaceutical companies engaged in drug discovery and process development.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel drug candidates, especially those targeting central nervous system (CNS) disorders and other specialized therapeutic areas.
• Medicinal Chemistry Research: Serves as a versatile scaffold for structure-activity relationship (SAR) studies and lead optimization in drug discovery programs.
• Process Chemistry Development: Used in the development and scale-up of robust synthetic routes for potential Active Pharmaceutical Ingredients (APIs).
• Chemical Biology Probes: Can be utilized in the development of molecular probes for studying biological pathways and target validation.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs and fine chemical manufacturers for custom synthesis projects requiring this specific molecular entity.

Basic Information

Product Name	2-(1-Aminocyclobut-1-Yl)Anisole Hydrochloride, 1-Amino-1-(2-Methoxyphenyl)Cyclobutane Hydrochloride
CAS No.	1228878-60-1
Molecular Formula	C11H16ClNO
Molecular Weight	213.70 g/mol
Synonyms	1-Amino-1-(2-methoxyphenyl)cyclobutane hydrochloride; 2-(1-Aminocyclobutyl)anisole hydrochloride; 1-(2-Methoxyphenyl)cyclobutanamine hydrochloride; 2-(1-Aminocyclobut-1-yl)anisole HCl; Cyclobutanamine, 1-(2-methoxyphenyl)-, hydrochloride (1:1); 1-(o-Methoxyphenyl)cyclobutanamine hydrochloride
EINECS	Contact for details

Quality Control

Our 2-(1-Aminocyclobut-1-Yl)Anisole Hydrochloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing to ensure identity, purity, and consistency. We provide a detailed Certificate of Analysis (COA) with every shipment, which includes data from HPLC, NMR, and other relevant spectroscopic methods. Our quality commitment aligns with the standards expected for pharmaceutical intermediates in development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent degradation from atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Related Substances (HPLC)	Individual impurity ≤ 0.5%; Total impurities ≤ 1.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.