Description

5-Bromo-2-(Trimethylsilyl)Furo[2,3-B]Pyridine CAS NO 1228665-74-4 is a high-purity, advanced heterocyclic building block featuring a fused furopyridine core. This compound is specifically engineered for use in sophisticated organic synthesis, where its unique bromine and trimethylsilyl functional groups offer versatile sites for further derivatization. It is a critical intermediate for researchers and process chemists in the pharmaceutical and agrochemical industries, enabling the development of novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: Serves as a key precursor in the synthesis of novel drug candidates, particularly in kinase inhibitor and central nervous system (CNS) active compound research.
• Agrochemical Synthesis: Used in the development of new herbicides, fungicides, and insecticides, leveraging its heterocyclic structure for bioactivity.
• Material Science Research: Acts as a building block for creating organic electronic materials, such as ligands for OLEDs or conductive polymers.
• Cross-Coupling Reactions: The bromine substituent makes it an excellent substrate for Suzuki, Stille, and other palladium-catalyzed cross-coupling reactions.
• Organometallic Chemistry: The trimethylsilyl group can be used as a protecting group or modified via ipso-desilylation reactions.
• Chemical Biology Probes: Utilized in the design and synthesis of molecular probes for studying biological pathways and target engagement.

Basic Information

Item	Detail
Product Name	5-Bromo-2-(Trimethylsilyl)Furo[2,3-B]Pyridine
CAS No.	1228665-74-4
Molecular Formula	C12H14BrNOSi
Molecular Weight	312.24 g/mol
Synonyms	5-Bromo-2-(trimethylsilyl)furo[2,3-b]pyridine; 5-Bromo-2-(trimethylsilyl)-furo[2,3-b]pyridine; 2-(Trimethylsilyl)-5-bromofuro[2,3-b]pyridine; Furo[2,3-b]pyridine, 5-bromo-2-(trimethylsilyl)-; 1228665-74-4; 5-Bromo-2-TMS-furo[2,3-b]pyridine
EINECS	Contact for details

Quality Control

Our 5-Bromo-2-(Trimethylsilyl)Furo[2,3-B]Pyridine is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and GC-MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical quality attributes. Our commitment to quality supports your R&D and scale-up processes with reliable, high-grade material.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and light-sensitive; therefore, containers must be kept sealed under an inert atmosphere (e.g., nitrogen or argon) when not in use to prevent degradation. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.