Description

2,7-Diazaspiro[3.5]Nonane-7-Carboxylic Acid, 5,5-Difluoro-, 1,1-Dimethylethyl Ester is a high-value, fluorinated spirocyclic building block used in advanced organic synthesis. Its unique rigid scaffold and fluorine substitution pattern make it a critical intermediate for developing novel bioactive molecules with enhanced metabolic stability and binding affinity. This compound is primarily sought after by pharmaceutical and agrochemical R&D organizations for constructing complex molecular architectures in drug discovery and crop protection programs.

Application

• Pharmaceutical Intermediate: A key synthon for the synthesis of protease inhibitors, kinase inhibitors, and other small-molecule therapeutics targeting CNS disorders, oncology, and infectious diseases.
• Agrochemical Research: Used in the development of new-generation herbicides, fungicides, and insecticides, where the difluoro-substituted spirocycle can impart improved biological activity and environmental profile.
• Chemical Biology Probe Development: Serves as a versatile scaffold for creating tool compounds and probes to study enzyme function and biological pathways.
• Material Science Precursor: Potential use in synthesizing specialty polymers and advanced materials with specific fluorinated properties.
• Medicinal Chemistry SAR Studies: Enables structure-activity relationship exploration by introducing conformational constraint and fluorine atoms into lead compounds.

Basic Information

Product Name	2,7-Diazaspiro[3.5]Nonane-7-Carboxylic Acid, 5,5-Difluoro-, 1,1-Dimethylethyl Ester
CAS No.	1228631-69-3
Molecular Formula	C12H20F2N2O2
Molecular Weight	262.30 g/mol
Synonyms	tert-Butyl 5,5-difluoro-2,7-diazaspiro[3.5]nonane-7-carboxylate; 7-Boc-5,5-difluoro-2,7-diazaspiro[3.5]nonane; 5,5-Difluoro-2,7-diazaspiro[3.5]nonane-7-carboxylic acid tert-butyl ester; 2,7-Diazaspiro[3.5]nonane-7-carboxylic acid, 5,5-difluoro-, 1,1-dimethylethyl ester; Boc-5,5-difluoro-2,7-diazaspiro[3.5]nonane; 1228631-69-3
EINECS	Contact for details

Quality Control

Our 2,7-Diazaspiro[3.5]Nonane-7-Carboxylic Acid, 5,5-Difluoro-, 1,1-Dimethylethyl Ester is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical characterization, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide detailed Certificates of Analysis (COA) with every shipment, documenting critical specifications. Our quality commitment supports applications requiring material of high and reliable purity for research and development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (typically 15-25°C). Keep the container tightly sealed to protect from moisture. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.