Description

(R)-2-(1-Aminoethyl)-4-Chlorophenol is a chiral organic compound featuring a phenol core substituted with a chlorinated aromatic ring and a chiral aminoethyl side chain. This specific stereochemistry makes it a valuable chiral building block and intermediate in the synthesis of more complex, biologically active molecules. It is primarily utilized by research institutions and pharmaceutical companies engaged in the development of new active pharmaceutical ingredients (APIs), agrochemicals, and specialty fine chemicals.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of novel APIs, particularly for central nervous system (CNS) agents, adrenergic receptor modulators, and other therapeutic compounds.
• Agrochemical Synthesis: Serves as a precursor in the production of advanced chiral pesticides and herbicides, where stereochemistry can significantly influence biological activity and environmental profile.
• Asymmetric Catalysis Ligand Precursor: Used in the preparation of chiral ligands for asymmetric synthesis, enabling the production of enantiomerically pure compounds.
• Fine Chemical Building Block: Employed in custom synthesis and contract manufacturing for creating complex, high-value specialty chemicals.
• Academic & Industrial Research: A critical reagent for methodological development in organic chemistry, medicinal chemistry, and process chemistry research.

Basic Information

Product Name	(R)-2-(1-Aminoethyl)-4-Chlorophenol
CAS No.	1228571-53-6
Molecular Formula	C8H10ClNO
Molecular Weight	171.62 g/mol
Synonyms	(R)-1-(4-Chloro-2-hydroxyphenyl)ethan-1-amine; (R)-1-(4-Chloro-2-hydroxyphenyl)ethylamine; (R)-2-(1-Aminoethyl)-4-chlorophenol; (R)-4-Chloro-2-(1-aminoethyl)phenol; (R)-α-Methyl-4-chloro-2-hydroxybenzylamine; (R)-1-(2-Hydroxy-4-chlorophenyl)ethylamine; (R)-4-Chloro-α-methylsalicylamine
EINECS	Contact for details

Quality Control

Our (R)-2-(1-Aminoethyl)-4-Chlorophenol is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity analysis by HPLC, to ensure it meets the high standards required for pharmaceutical and advanced synthetic applications. A detailed Certificate of Analysis (COA) providing specifications for identity, purity, enantiomeric excess, and related substances is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under dry conditions to prevent degradation. Keep away from incompatible materials such as strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white powder or crystalline solid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Related Substances (HPLC)	Total impurities ≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.