Description

(5S)-5-Amino-5,6,7,8-Tetrahydronaphthalen-1-Ol CAS NO 1228570-52-2 is a high-purity chiral amine derivative of tetrahydronaphthalene, serving as a critical advanced pharmaceutical intermediate. Its value lies in its role as a sophisticated building block for synthesizing complex, biologically active molecules, particularly in the development of chiral drugs. This compound is essential for research and manufacturing organizations in the pharmaceutical, agrochemical, and fine chemical sectors seeking to develop novel therapeutic agents with high stereochemical purity.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the research and development of novel active pharmaceutical ingredients (APIs), particularly in central nervous system (CNS) and cardiovascular drug candidates.
• Asymmetric Synthesis: Utilized as a chiral auxiliary or precursor in asymmetric catalytic reactions to construct complex molecular architectures with high enantiomeric excess.
• Agrochemical Research: Serves as a building block in the synthesis of new chiral pesticides and herbicides, where specific stereochemistry can influence biological activity and environmental safety.
• Ligand and Catalyst Development: Used to develop novel chiral ligands for transition metal catalysis, enabling more efficient and selective synthetic routes.
• Fine Chemical Production: Employed in the custom synthesis of specialty chemicals, flavors, and fragrances requiring precise stereochemical control.
• Academic & R&D: A valuable compound for medicinal chemistry research, process chemistry development, and methodological studies in academic and industrial laboratories.

Basic Information

Product Name	(5S)-5-Amino-5,6,7,8-Tetrahydronaphthalen-1-Ol
CAS No.	1228570-52-2
Molecular Formula	C10H13NO
Molecular Weight	163.22 g/mol
Synonyms	(5S)-1-Amino-5,6,7,8-tetrahydronaphthalen-5-ol; (5S)-5-Amino-5,6,7,8-tetrahydro-1-naphthol; (5S)-5-Amino-1,2,3,4-tetrahydronaphthalen-1-ol; 1-Naphthol, 5-amino-5,6,7,8-tetrahydro-, (5S)-; (S)-5-Amino-5,6,7,8-tetrahydronaphthalen-1-ol; 5-Amino-5,6,7,8-tetrahydronaphthalen-1-ol (S-enantiomer); (5S)-5-Amino-1,2,3,4-tetrahydro-1-naphthalenol
EINECS	Contact for details

Quality Control

Our (5S)-5-Amino-5,6,7,8-Tetrahydronaphthalen-1-Ol is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity verification, to ensure it meets the high standards required for advanced synthetic applications. Certificates of Analysis (COA) detailing identity, purity, and enantiomeric excess are provided with every shipment. We support compliance with cGMP, ICH guidelines, and relevant pharmacopeial standards as required for pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to exclude moisture. For long-term storage, consider using desiccants or storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Residual Solvents (GC)	Complies with ICH Q3C

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.