Description

(S)-8-(Trifluoromethyl)Chroman-4-Amine is a chiral, fluorinated organic building block of significant interest in advanced chemical synthesis. Its core value lies in the combination of a rigid chroman scaffold with a stereogenic center and a metabolically stable trifluoromethyl group, making it a privileged intermediate for creating novel bioactive molecules. This compound is primarily needed by research and development teams in the pharmaceutical and agrochemical industries for applications in medicinal chemistry and crop protection.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the research and development of new active pharmaceutical ingredients (APIs), particularly in central nervous system (CNS) and cardiovascular drug discovery.
• Medicinal Chemistry: Used in structure-activity relationship (SAR) studies and lead optimization to modulate the potency, selectivity, and pharmacokinetic properties of drug candidates.
• Agrochemical Research: Serves as a building block for developing novel herbicides, fungicides, and insecticides, leveraging the bioactivity-enhancing properties of the trifluoromethyl group.
• Chiral Ligand/ Catalyst Precursor: Potential use in the synthesis of chiral ligands for asymmetric catalysis due to its defined stereochemistry.
• Chemical Biology Probe: Useful for creating molecular probes to study enzyme function and biological pathways.
• Custom Synthesis & Contract Manufacturing: A critical starting material for custom synthesis projects requiring high-purity, complex fluorinated chiral amines.

Basic Information

Product Name	(S)-8-(Trifluoromethyl)Chroman-4-Amine
CAS No.	1228569-07-0
Molecular Formula	C10H10F3NO
Molecular Weight	217.19 g/mol
Synonyms	(4S)-8-(Trifluoromethyl)-3,4-dihydro-2H-1-benzopyran-4-amine; (S)-8-(Trifluoromethyl)-3,4-dihydro-2H-chromen-4-amine; (S)-8-(Trifluoromethyl)chroman-4-ylamine; (S)-4-Amino-8-(trifluoromethyl)chroman; 8-(Trifluoromethyl)chroman-4-amine (S-enantiomer); (S)-8-Trifluoromethylchroman-4-amine; (S)-TFC-Amine
EINECS	Contact for details

Quality Control

Our (S)-8-(Trifluoromethyl)Chroman-4-Amine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity determination, to ensure it meets the high standards required for research and development. Certificates of Analysis (COA) detailing identity, purity (HPLC/GC), chiral excess, and impurity profiles are available upon request to support your regulatory and quality assurance needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (typically 15-25°C). For long-term storage, consider storing under an inert atmosphere to maintain optimal stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR / NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 98.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.