Description

(R)-4-Bromo-2,3-Dihydro-1H-Inden-1-Amine-Hcl CAS NO 1228556-71-5 is a chiral amine hydrochloride salt, a high-purity building block of significant importance in advanced organic synthesis. Its value lies in its role as a key intermediate for constructing complex, optically active molecules, particularly in pharmaceutical research and development. This compound is essential for medicinal chemists and process development scientists working on novel therapeutics, including central nervous system (CNS) agents and enzyme inhibitors.

Application

• Pharmaceutical Intermediate: A critical chiral building block for the synthesis of novel active pharmaceutical ingredients (APIs), especially in neurological and psychiatric drug discovery.
• Asymmetric Synthesis: Used in the preparation of enantiomerically pure compounds for biological testing and development.
• Medicinal Chemistry Research: Serves as a versatile scaffold for structure-activity relationship (SAR) studies and lead optimization in drug discovery programs.
• Chemical Biology Probes: Employed in the development of molecular probes to study biological pathways and enzyme functions.
• Catalyst Ligand Precursor: Can be utilized in the synthesis of chiral ligands for asymmetric catalysis.
• Reference Standard: Serves as a high-purity analytical standard for quality control and method development in pharmaceutical analysis.

Basic Information

Product Name	(R)-4-Bromo-2,3-Dihydro-1H-Inden-1-Amine Hydrochloride
CAS No.	1228556-71-5
Molecular Formula	C9H11BrClN
Molecular Weight	248.55 g/mol
Synonyms	(1R)-4-Bromo-2,3-dihydro-1H-inden-1-amine hydrochloride; (R)-4-Bromoindan-1-amine hydrochloride; (R)-1-Amino-4-bromoindane hydrochloride; 4-Bromo-(1R)-indan-1-amine hydrochloride; (R)-4-Bromo-1-indanamine hydrochloride; (1R)-4-Bromo-2,3-dihydro-1H-inden-1-amine HCl; (R)-4-Bromo-2,3-dihydro-1H-inden-1-amine HCl salt
EINECS	Contact for details

Quality Control

Our (R)-4-Bromo-2,3-Dihydro-1H-Inden-1-Amine-Hcl is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity suitable for research and development. Each lot undergoes comprehensive analytical characterization, including chiral purity verification by HPLC. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting identity, purity, and impurity profiles.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to prevent moisture absorption, which can affect stability and handling properties.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥97.0%
Chiral Purity (HPLC)	≥98.0% ee
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.