Description

2-Chloro-1,3-Bis(2,6-Diisopropylphenyl)-1H-Imidazol-3-Ium Chloride is a high-value, advanced N-heterocyclic carbene (NHC) precursor salt, essential for generating highly active and stable organocatalysts. This compound matters because it provides a reliable and consistent source of a sterically hindered, electron-rich NHC ligand, which is critical for controlling reactivity and selectivity in demanding synthetic transformations. Industrial researchers and process chemists in pharmaceutical, agrochemical, and advanced materials R&D need this reagent to develop novel catalytic processes, particularly for cross-coupling, polymerization, and small molecule activation.

Application

• Organometallic Catalyst Synthesis: As a key precursor for generating sterically demanding N-heterocyclic carbene (NHC) ligands used in palladium, nickel, gold, and other transition metal complexes for cross-coupling reactions (e.g., Suzuki, Heck, Buchwald-Hartwig).
• Pharmaceutical Intermediate Manufacturing: Enabling the synthesis of complex active pharmaceutical ingredients (APIs) where precise catalytic control is required for chiral center formation or difficult bond constructions.
• Polymerization Catalysis: Serving as a catalyst component in the ring-opening polymerization (ROP) of cyclic esters and olefin metathesis polymerization for producing specialized polymers and materials.
• Agrochemical Research & Development: Facilitating the creation of novel crop protection agents and pesticides through advanced catalytic methodologies in process chemistry.
• Materials Science: Used in the development of novel organic electronic materials, metal-organic frameworks (MOFs), and surface modifiers where tailored NHC-metal interactions are crucial.
• Academic & Industrial R&D: A fundamental reagent for methodological development in synthetic organic and organometallic chemistry laboratories worldwide.

Basic Information

Product Name	2-Chloro-1,3-Bis(2,6-Diisopropylphenyl)-1H-Imidazol-3-Ium Chloride
CAS No.	1228185-09-8
Molecular Formula	C27H37Cl2N2
Molecular Weight	460.50 g/mol
Synonyms	1,3-Bis(2,6-diisopropylphenyl)-2-chloroimidazolium chloride; SIPr·HCl; 2-Chloro-1,3-bis(2,6-di-iso-propylphenyl)imidazolium chloride; NHC precursor SIPr; 1H-Imidazolium, 2-chloro-1,3-bis(2,6-diisopropylphenyl)-, chloride; IPr*HCl analog; Sterically hindered imidazolium salt; N-Heterocyclic Carbene Salt
EINECS	Contact for details

Quality Control

Our 2-Chloro-1,3-Bis(2,6-Diisopropylphenyl)-1H-Imidazol-3-Ium Chloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, NMR for structural confirmation, and residual solvent analysis, to ensure it meets the high standards required for research and process development. Certificates of Analysis (COA) with complete analytical data are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and light-sensitive; therefore, containers must be kept tightly sealed and desiccated when not in use to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.