Description

1,9-Diazaspiro[5.5]undecane-1-carboxylic acid, 1,1-dimethylethyl ester, hydrochloride (1:1) is a high-purity, protected spirocyclic diamine building block essential for advanced organic synthesis. This compound is valued for its role as a key chiral intermediate in the development of complex pharmaceutical molecules, particularly in medicinal chemistry and drug discovery. It is primarily utilized by research institutions and pharmaceutical companies engaged in the synthesis of novel active pharmaceutical ingredients (APIs) and fine chemicals. The hydrochloride salt form enhances its stability and handling properties for precise synthetic applications.

Application

• Pharmaceutical Intermediate: A critical chiral building block in the synthesis of complex drug candidates, particularly for central nervous system (CNS) and antiviral targets.
• Medicinal Chemistry Research: Used in lead optimization and structure-activity relationship (SAR) studies to develop novel therapeutic agents.
• Peptidomimetic Synthesis: Serves as a constrained scaffold for designing peptide mimics with enhanced metabolic stability and bioavailability.
• Asymmetric Catalysis Ligand Precursor: Can be utilized to develop novel chiral ligands for asymmetric synthesis.
• Chemical Biology Probes: Employed in the creation of molecular probes to study biological pathways and protein function.
• Fine Chemical Production: Used in the multi-step synthesis of high-value, specialized fine chemicals.

Basic Information

Product Name	1,9-Diazaspiro[5.5]undecane-1-carboxylic acid, 1,1-dimethylethyl ester, hydrochloride (1:1)
CAS No.	1228182-67-9
Molecular Formula	C14H27N2O2 • HCl
Molecular Weight	300.84 g/mol
Synonyms	tert-Butyl 1,9-diazaspiro[5.5]undecane-1-carboxylate hydrochloride; 1-Boc-1,9-diazaspiro[5.5]undecane hydrochloride; 1-N-Boc-1,9-diazaspiro[5.5]undecane hydrochloride; 1,9-Diazaspiro[5.5]undecane-1-carboxylic acid tert-butyl ester hydrochloride; Boc-1,9-diazaspiro[5.5]undecane HCl; 1-(tert-Butoxycarbonyl)-1,9-diazaspiro[5.5]undecane hydrochloride
EINECS	Contact for details

Quality Control

Our 1,9-Diazaspiro[5.5]undecane-1-carboxylic acid, 1,1-dimethylethyl ester, hydrochloride (1:1) is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure high chemical purity and structural identity. Certificates of Analysis (COA) detailing all specifications are provided and available upon request, supporting compliance with research and development standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.