Description

1-Bromo-3-Cyclopropyl-5-Methoxybenzene is a high-purity, advanced pharmaceutical intermediate and versatile building block in organic synthesis. This compound is valued for its unique molecular architecture, which incorporates bromine, cyclopropyl, and methoxy functional groups on a benzene core, enabling precise structural modifications. It is primarily utilized by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and material science industries for the synthesis of novel active compounds.

Application

• Pharmaceutical Intermediate: A key building block for the synthesis of active pharmaceutical ingredients (APIs), particularly in drug discovery programs targeting CNS disorders, oncology, and anti-infectives.
• Agrochemical Synthesis: Used in the research and development of new herbicides, fungicides, and insecticides, leveraging the bioactivity of the cyclopropyl moiety.
• Material Science Precursor: Serves as a monomer or functionalizing agent in the development of advanced polymers, liquid crystals, and organic electronic materials.
• Cross-Coupling Reactions: The bromine atom makes it an excellent substrate for palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Heck, Stille) to create complex biaryl structures.
• Chemical Research: Employed in academic and industrial laboratories for methodological studies and the construction of complex molecular libraries for screening.
• Fine Chemical Production: Integral to the multi-step synthesis of specialty chemicals, dyes, and fragrances requiring specific aromatic substitution patterns.

Basic Information

Product Name	1-Bromo-3-Cyclopropyl-5-Methoxybenzene
CAS No.	1227692-30-9
Molecular Formula	C10H11BrO
Molecular Weight	227.10 g/mol
Synonyms	3-Bromo-5-Cyclopropylanisole; 5-Bromo-1-Cyclopropyl-3-Methoxybenzene; Benzene, 1-bromo-3-cyclopropyl-5-methoxy-; 3-Cyclopropyl-5-methoxybromobenzene; 1-Bromo-3-cyclopropyl-5-methoxy-benzene
EINECS	Contact for details

Quality Control

Every batch of 1-Bromo-3-Cyclopropyl-5-Methoxybenzene is manufactured under strict quality management systems and undergoes rigorous analytical testing to ensure identity, purity, and consistency. Our standard grade typically meets a purity specification of ≥97% (by HPLC), with custom purities up to 99%+ available. A comprehensive Certificate of Analysis (COA) detailing results for assay, identity, and impurity profiles is provided with each shipment to support your quality and regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from heat, sparks, and open flame. This material is light-sensitive (store away from light).

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 97.0%
Related Substances (HPLC)	Total impurities ≤ 3.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.