Description

(1R,6S)-6-(tert-Butoxycarbonylamino)Cyclohex-3-Enecarboxylic Acid CAS NO 1226812-49-2 is a high-purity, chiral building block featuring a protected amino group and a carboxylic acid functionality. This compound is critical for the synthesis of complex, biologically active molecules where stereochemical integrity is paramount. It is primarily sought after by research and development teams in the pharmaceutical and agrochemical industries for constructing novel active ingredients and advanced intermediates.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the development of novel drug candidates, particularly in protease inhibitor and small molecule therapeutic programs.
• Peptidomimetics Synthesis: Used to introduce constrained cyclohexene scaffolds into peptide backbones to enhance metabolic stability and binding affinity.
• Agrochemical Research: Serves as a building block for creating chiral active ingredients with specific modes of action in crop protection products.
• Chemical Biology Probes: Employed in the design and synthesis of molecular probes for studying enzyme function and biological pathways.
• Asymmetric Catalysis Ligand Precursor: Can be utilized to develop novel chiral ligands for asymmetric synthesis applications.
• Custom Synthesis & Contract Manufacturing: A fundamental starting material for custom synthesis projects requiring high stereochemical purity and reliable supply.

Basic Information

Product Name	(1R,6S)-6-(tert-Butoxycarbonylamino)Cyclohex-3-Enecarboxylic Acid
CAS No.	1226812-49-2
Molecular Formula	C12H19NO4
Molecular Weight	241.28 g/mol
Synonyms	(1R,6S)-6-[(tert-Butoxycarbonyl)amino]-3-cyclohexene-1-carboxylic Acid; (1R,6S)-6-(Boc-amino)cyclohex-3-ene-1-carboxylic Acid; Boc-(1R,6S)-6-amino-3-cyclohexene-1-carboxylic Acid; (1R,6S)-Boc-Achc-OH; trans-6-(tert-Butoxycarbonylamino)cyclohex-3-enecarboxylic Acid (enantiomer); (1R,6S)-6-(tert-Butoxycarbonylamino)-1,2,3,6-tetrahydrobenzoic Acid; Cyclohex-3-ene-1-carboxylic acid, 6-[(1,1-dimethylethoxy)carbonyl]amino]-, (1R,6S)-
EINECS	Contact for details

Quality Control

Our (1R,6S)-6-(tert-Butoxycarbonylamino)Cyclohex-3-Enecarboxylic Acid is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification by HPLC, to ensure it meets the stringent requirements for advanced pharmaceutical intermediates. Certificates of Analysis (COA) detailing identity, purity, and enantiomeric excess are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Enantiomeric Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.