Description

2-(3,4-Difluorophenyl)Nicotinic Acid is a high-purity, fluorinated nicotinic acid derivative serving as a critical building block in advanced organic synthesis. This compound is valued for its unique molecular structure, which incorporates a difluorophenyl moiety to modulate the electronic and steric properties of target molecules. It is primarily sought after by research and development teams in the pharmaceutical and agrochemical sectors for the synthesis of novel active ingredients, particularly in the development of kinase inhibitors and other biologically active compounds.

Application

• Pharmaceutical Intermediate: A key synthetic precursor in the research and development of novel drug candidates, especially kinase inhibitors and other small-molecule therapeutics.
• Agrochemical Synthesis: Used in the development of new pesticides and herbicides, where the fluorinated aromatic ring can enhance biological activity and environmental stability.
• Chemical Research & Development: Serves as a versatile scaffold in medicinal chemistry for structure-activity relationship (SAR) studies and lead optimization.
• Material Science: Potential use as a monomer or functional additive in the synthesis of specialty polymers and advanced materials.
• Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects and scale-up production.

Basic Information

Product Name	2-(3,4-Difluorophenyl)Nicotinic Acid
CAS No.	1225511-07-8
Molecular Formula	C12H7F2NO2
Molecular Weight	235.19 g/mol
Synonyms	2-(3,4-Difluorophenyl)pyridine-3-carboxylic acid; 3-Pyridinecarboxylic acid, 2-(3,4-difluorophenyl)-; Nicotinic acid, 2-(3,4-difluorophenyl)-; 2-(3,4-Difluorophenyl)-3-pyridinecarboxylic acid; 2-(3,4-Difluorophenyl)nicotinic acid
EINECS	Contact for details

Quality Control

Our 2-(3,4-Difluorophenyl)Nicotinic Acid is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. Each lot is subjected to rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to confirm identity and purity. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with every shipment. We support cGMP standards for pharmaceutical applications and can accommodate custom purity requirements upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under dry, inert conditions to prevent degradation. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.