Description

1,2,4-Oxadiazole-3-Methanamine, α,5-Dimethyl-, Hydrochloride (1:1), (αr)- is a high-purity chiral building block and pharmaceutical intermediate of significant commercial interest. Its value lies in its defined stereochemistry and functionalized oxadiazole core, which is crucial for modulating the biological activity and physicochemical properties of advanced drug candidates. This compound is primarily needed by research institutions and pharmaceutical companies engaged in the discovery and development of new therapeutic agents, particularly in areas requiring sophisticated heterocyclic chemistry.

Application

• Pharmaceutical Intermediate: Serves as a key chiral synthon in the multi-step synthesis of novel Active Pharmaceutical Ingredients (APIs).
• Medicinal Chemistry Research: Used extensively in hit-to-lead and lead optimization campaigns to explore structure-activity relationships (SAR).
• Agrochemical Development: Potential application as a building block for creating new crop protection agents with specific modes of action.
• Ligand Synthesis: Can be utilized in the preparation of specialized ligands for catalysis or diagnostic applications.
• Chemical Biology Probes: Employed in the design and synthesis of molecular probes for studying biological pathways.
• Custom Synthesis: A starting material for contract research and manufacturing organizations (CROs/CMOs) producing bespoke compounds for clients.

Basic Information

Item	Details
Product Name	1,2,4-Oxadiazole-3-Methanamine, α,5-Dimethyl-, Hydrochloride (1:1), (αr)-
CAS No.	1225462-38-3
Molecular Formula	C6H12N3O·HCl
Molecular Weight	177.64 g/mol
Synonyms	(R)-α,5-Dimethyl-1,2,4-oxadiazole-3-methanamine hydrochloride; (R)-3-(Aminomethyl)-5-methyl-1,2,4-oxadiazole hydrochloride; (R)-5-Methyl-3-[(aminomethyl)]-1,2,4-oxadiazole hydrochloride; AR-1,2,4-Oxadiazole amine HCl; Chiral 1,2,4-oxadiazole derivative; (R)-enantiomer of α,5-dimethyl-1,2,4-oxadiazole-3-methanamine HCl
EINECS	Contact for details

Quality Control

Every batch of 1,2,4-Oxadiazole-3-Methanamine, α,5-Dimethyl-, Hydrochloride (1:1), (αr)- is manufactured under a strict quality management system. We employ advanced analytical techniques, including chiral HPLC and NMR, to ensure identity, purity, and enantiomeric excess meet the stringent requirements of pharmaceutical R&D. Comprehensive Certificates of Analysis (COA) documenting all critical quality attributes are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under an inert atmosphere or in a desiccated environment after opening to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (IR)	Conforms
Purity (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.