Description

tert-Butyl 2-(6-Bromo-2-oxo-3,4-dihydroquinolin-1(2H)-yl)acetate is a high-purity, advanced pharmaceutical intermediate of significant synthetic utility. This compound matters for its role as a key building block in the development of novel active pharmaceutical ingredients (APIs), particularly within medicinal chemistry research. It is primarily needed by R&D scientists and process chemists in the pharmaceutical, agrochemical, and fine chemical industries for constructing complex heterocyclic frameworks.

Application

• Pharmaceutical Intermediate: A critical precursor in the synthesis of complex drug candidates, particularly those targeting central nervous system (CNS) disorders and oncology.
• Medicinal Chemistry Research: Serves as a versatile scaffold for structure-activity relationship (SAR) studies and lead optimization in drug discovery programs.
• Agrochemical Synthesis: Used in the development of novel herbicides and pesticides that require functionalized quinoline derivatives.
• Fine Chemical Manufacturing: Employed in the production of specialty chemicals, dyes, and functional materials.
• Academic & Contract Research: A valuable reagent for universities and CROs (Contract Research Organizations) conducting synthetic organic chemistry and methodology development.
• Process Development & Scale-up: Suitable for optimization and kilogram-scale production under cGMP (current Good Manufacturing Practice) guidelines for clinical trial material supply.

Basic Information

Product Name	tert-Butyl 2-(6-Bromo-2-oxo-3,4-dihydroquinolin-1(2H)-yl)acetate
CAS No.	1224927-63-2
Molecular Formula	C₁₅H₁₈BrNO₃
Molecular Weight	340.21 g/mol
Synonyms	1,2,3,4-Tetrahydro-6-bromo-1-[(1,1-dimethylethoxy)carbonylmethyl]-2-oxoquinoline; 6-Bromo-1-(2-tert-butoxy-2-oxoethyl)-3,4-dihydroquinolin-2(1H)-one; 6-Bromo-1-(2-tert-butoxy-2-oxoethyl)-1,2,3,4-tetrahydroquinolin-2-one; tert-Butyl (6-bromo-2-oxo-1,2,3,4-tetrahydroquinolin-1-yl)acetate; 6-Bromo-2-oxo-1,2,3,4-tetrahydroquinoline-1-acetic acid tert-butyl ester; 1-(tert-Butoxycarbonylmethyl)-6-bromo-3,4-dihydro-2(1H)-quinolinone
EINECS	Contact for details

Quality Control

Our tert-Butyl 2-(6-Bromo-2-oxo-3,4-dihydroquinolin-1(2H)-yl)acetate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure high purity and consistent performance, meeting the stringent requirements for pharmaceutical R&D and scale-up. Comprehensive Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This material is light-sensitive (store away from light) and hygroscopic (moisture-sensitive). Keep container tightly sealed under an inert atmosphere to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference standard
Assay (HPLC)	≥ 98.0%
Purity (HPLC, Area %)	≥ 99.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.