Description

2-Boc-Amino-6-Chloro-Nicotinic Acid is a high-purity, protected nicotinic acid derivative serving as a critical building block in advanced organic synthesis. Its primary value lies in providing a versatile and reactive scaffold for constructing complex heterocyclic molecules, particularly in pharmaceutical research and development. This compound is essential for medicinal chemists and process development scientists in the pharmaceutical, agrochemical, and fine chemical industries who require reliable, high-quality intermediates for API synthesis and novel compound libraries.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of active pharmaceutical ingredients (APIs), especially those containing complex pyridine or nicotinic acid cores.
• Medicinal Chemistry Research: Serves as a versatile building block for constructing targeted molecular libraries in drug discovery programs for various therapeutic areas.
• Peptidomimetic Synthesis: Used in the preparation of peptide analogs and mimetics where the Boc-protected amino group and carboxylic acid functionality are crucial.
• Agrochemical Development: Intermediate in the research and production of advanced herbicides, insecticides, and fungicides.
• Chemical Biology Probes: Utilized in the synthesis of labeled compounds and molecular probes for studying biological pathways and target engagement.
• Custom Synthesis & Contract Manufacturing: A fundamental starting material for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) producing specialized fine chemicals.

Basic Information

Product Name	2-Boc-Amino-6-Chloro-Nicotinic Acid
CAS No.	1224194-44-8
Molecular Formula	C11H13ClN2O4
Molecular Weight	272.69 g/mol
Synonyms	6-Chloro-2-[(tert-butoxycarbonyl)amino]nicotinic acid; 2-[(tert-Butoxycarbonyl)amino]-6-chloropyridine-3-carboxylic acid; 2-(Boc-amino)-6-chloro-3-pyridinecarboxylic acid; tert-Butyl (6-chloro-3-carboxypyridin-2-yl)carbamate; Boc-6-Chloro-2-aminonicotinic Acid; 2-Amino-6-chloronicotinic acid tert-butyl carbamate; 2-Boc-Amino-6-chloro-3-pyridinecarboxylic acid
EINECS	Contact for details

Quality Control

Our 2-Boc-Amino-6-Chloro-Nicotinic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical quality attributes. Our production adheres to cGMP principles where applicable, ensuring the material is suitable for demanding research and development applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to exclude moisture. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.