Description

3-(Trifluoromethyl)Azetidine Hydrochloride is a high-purity, advanced pharmaceutical intermediate featuring a unique azetidine ring system substituted with a trifluoromethyl group. This compound is valued for its role in modulating the physicochemical properties of active molecules, particularly enhancing metabolic stability and membrane permeability. It is primarily utilized by research and development teams in the pharmaceutical and agrochemical sectors for the synthesis of novel bioactive compounds, including potential drug candidates and crop protection agents.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of novel active pharmaceutical ingredients (APIs), particularly for central nervous system (CNS) and anti-infective drug discovery programs.
• Agrochemical Synthesis: Used in the research and development of advanced herbicides and fungicides, where the trifluoromethyl group can improve biological activity and environmental stability.
• Ligand and Catalyst Development: Serves as a precursor for creating specialized ligands in asymmetric catalysis and organometallic chemistry.
• Material Science Research: Investigated as a monomer or additive for developing polymers with specific fluorinated properties, such as enhanced chemical resistance or altered surface characteristics.
• Chemical Biology Probes: Employed in the design and synthesis of molecular probes for studying enzyme function and biological pathways.

Basic Information

Product Name	3-(Trifluoromethyl)Azetidine Hydrochloride
CAS No.	1221272-90-7
Molecular Formula	C4H7F3N • HCl
Molecular Weight	177.56 g/mol
Synonyms	3-(Trifluoromethyl)azetidine HCl; 3-(Trifluoromethyl)azetidine hydrochloride; Azetidine, 3-(trifluoromethyl)-, hydrochloride (1:1); 1-Azetidinecarboxylic acid, 3-(trifluoromethyl)-, hydrochloride; 3-Trifluoromethylazetidine HCl salt
EINECS	Contact for details

Quality Control

Every batch of 3-(Trifluoromethyl)Azetidine Hydrochloride is manufactured under a strict quality management system and undergoes comprehensive analytical testing to ensure identity, purity, and consistency. Our products are suitable for use in research and development under cGMP guidelines where applicable. A detailed Certificate of Analysis (COA) providing batch-specific results for purity, impurities, and other critical parameters is supplied with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.