Description

2-(Trifluoromethoxy)Isonicotinic Acid is a high-purity, fluorinated pyridine derivative serving as a critical building block in advanced organic synthesis. Its unique structure, featuring both a trifluoromethoxy group and a carboxylic acid functionality, makes it an invaluable intermediate for creating compounds with enhanced metabolic stability and bioavailability. This product is essential for research and development chemists in the pharmaceutical and agrochemical industries, particularly for the synthesis of novel active ingredients and complex molecules.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of active pharmaceutical ingredients (APIs), especially in drug discovery programs targeting central nervous system (CNS) disorders, inflammation, and infectious diseases.
• Agrochemical Synthesis: Used in the development of next-generation herbicides, fungicides, and insecticides, where the trifluoromethoxy group can improve lipophilicity and biological activity.
• Ligand and Catalyst Development: Serves as a precursor for creating specialized ligands in transition metal catalysis and organocatalysis.
• Material Science Research: Employed in the synthesis of advanced polymers and liquid crystals, where fluorinated aromatic units impart unique thermal and chemical resistance properties.
• Custom Synthesis and Contract Manufacturing: A vital starting material for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) serving the life sciences sector.

Basic Information

Product Name	2-(Trifluoromethoxy)Isonicotinic Acid
CAS No.	1221171-98-7
Molecular Formula	C7H4F3NO3
Molecular Weight	207.11 g/mol
Synonyms	2-(Trifluoromethoxy)pyridine-4-carboxylic acid; 4-Pyridinecarboxylic acid, 2-(trifluoromethoxy)-; Isonicotinic acid, 2-(trifluoromethoxy)-; 2-Trifluoromethoxyisonicotinic acid; 2-(Trifluoromethoxy)isonicotinate
EINECS	Contact for details

Quality Control

Our 2-(Trifluoromethoxy)Isonicotinic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via NMR and IR spectroscopy, to ensure it meets the high standards required for research and commercial synthesis. A comprehensive Certificate of Analysis (COA) detailing all test results is provided with every shipment to guarantee traceability and compliance with your specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Keep away from strong bases and oxidizing agents. For long-term storage, consider storing under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.