Description

4-Fmoc-Aminomethyl-Aniline Hydrochloride is a key protected amino acid derivative essential for modern solid-phase peptide synthesis (SPPS). Its primary value lies in providing a versatile, orthogonally protected building block that allows for the controlled introduction of functionalized aniline moieties into complex peptide sequences. This compound is critically needed by research institutions and pharmaceutical companies engaged in the development of peptide-based therapeutics, diagnostics, and chemical probes.

Application

• As a specialized building block in Fmoc-based solid-phase peptide synthesis (SPPS) for introducing functionalized aromatic amines.
• For the synthesis of peptide nucleic acid (PNA) monomers and other backbone-modified peptide analogs.
• In the research and development of targeted peptide-drug conjugates (PDCs) and bioactive peptides.
• As a key intermediate for creating fluorescently labeled peptides and molecular imaging agents.
• For the preparation of custom amino acids and non-natural amino acid residues in medicinal chemistry.
• In the synthesis of scaffolds for combinatorial chemistry and chemical library generation.

Basic Information

Product Name	4-Fmoc-Aminomethyl-Aniline Hydrochloride
CAS No.	1220040-04-9
Molecular Formula	C23H22N2O2 • HCl
Molecular Weight	410.90 g/mol
Synonyms	N-[(4-Aminophenyl)methyl]-9H-fluoren-9-ylmethoxycarbonylamine hydrochloride; 4-[(Fmoc-amino)methyl]aniline hydrochloride; 4-(Fmoc-aminomethyl)aniline HCl; 4-Aminobenzyl-Fmoc-amine hydrochloride; Fmoc-4-aminobenzylamine hydrochloride; Nα-Fmoc-4-aminobenzylamine hydrochloride; 1-[(9H-Fluoren-9-ylmethoxy)carbonylamino]methyl-4-aminobenzene hydrochloride
EINECS	Contact for details

Quality Control

Our 4-Fmoc-Aminomethyl-Aniline Hydrochloride is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity suitable for sensitive synthetic applications. Each lot undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation. A Certificate of Analysis (COA) detailing all specifications is provided with every shipment to support your quality assurance and regulatory documentation.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This material is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccant and inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC/IR)	Conforms to reference standard
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 20 ppm
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.