Description

6-Iodo-Pyrazolo[1,5-A]Pyridine-3-Carboxylic Acid is a high-value, halogenated heterocyclic building block essential for advanced organic synthesis. This compound matters because its unique fused pyrazolopyridine scaffold, functionalized with both a carboxylic acid and an iodine atom, provides versatile handles for derivatization and cross-coupling reactions, enabling the rapid construction of complex molecular architectures. It is primarily needed by medicinal chemistry and pharmaceutical R&D teams for the development of new drug candidates, particularly in areas targeting kinase inhibition and other biological pathways.

Application

• Pharmaceutical Intermediate: Serves as a critical precursor in the synthesis of novel active pharmaceutical ingredients (APIs) and investigational new drugs.
• Medicinal Chemistry Research: Used as a versatile scaffold for constructing compound libraries via Suzuki, Sonogashira, and other palladium-catalyzed cross-coupling reactions utilizing the iodine substituent.
• Agrochemical Development: Employed in the research and synthesis of new herbicides, fungicides, and insecticides that require complex heterocyclic cores.
• Material Science Precursor: Acts as a building block for creating organic electronic materials, ligands for catalysts, and specialty polymers.
• Bioconjugation & Probe Synthesis: The carboxylic acid group allows for amide coupling to biomolecules or fluorescent tags, useful in creating biochemical probes.

Basic Information

Product Name	6-Iodo-Pyrazolo[1,5-A]Pyridine-3-Carboxylic Acid
CAS No.	1220039-46-2
Molecular Formula	C8H5IN2O2
Molecular Weight	288.04 g/mol
Synonyms	6-Iodopyrazolo[1,5-a]pyridine-3-carboxylic acid; 6-Iodo-1H-pyrazolo[1,5-a]pyridine-3-carboxylic acid; 1220039-46-2; 6-Iodo-pyrazolo[1,5-a]pyridine-3-carboxylic acid; 6-Iodo-3-pyrazolo[1,5-a]pyridinecarboxylic Acid; Pyrazolo[1,5-a]pyridine-3-carboxylic acid, 6-iodo-
EINECS	Contact for details

Quality Control

Our 6-Iodo-Pyrazolo[1,5-A]Pyridine-3-Carboxylic Acid is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity, suitable for sensitive research and development applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We are committed to meeting the stringent requirements of cGMP and ISO standards for advanced chemical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%
Heavy Metals (as Pb)	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.