Description

3-[(2-Nitrophenoxy)Methyl]Pyrrolidinehydrochloride is a high-purity, advanced pharmaceutical intermediate with the CAS number 1220016-33-0. This compound is critical for the synthesis of complex active pharmaceutical ingredients (APIs), particularly in research and development of novel therapeutic agents. It is primarily utilized by pharmaceutical R&D laboratories, fine chemical manufacturers, and contract research organizations (CROs) engaged in medicinal chemistry and process development.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of novel drug candidates, particularly in central nervous system (CNS) and oncology research.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization for new chemical entities.
• Process Chemistry Development: Serves as a critical precursor in scaling up synthetic routes from laboratory to pilot plant scale.
• Custom Synthesis: Employed by fine chemical suppliers for the contract manufacturing of specialized APIs and reference standards.
• Academic Research: Utilized in university and institutional labs for studying heterocyclic chemistry and reaction mechanisms.

Basic Information

Product Name	3-[(2-Nitrophenoxy)Methyl]Pyrrolidinehydrochloride
CAS No.	1220016-33-0
Molecular Formula	C11H14N2O3·HCl
Molecular Weight	258.70 g/mol
Synonyms	3-[(2-Nitrophenoxy)methyl]pyrrolidine hydrochloride; 1-(2-Nitrophenoxymethyl)pyrrolidine hydrochloride; Pyrrolidine, 3-[(2-nitrophenoxy)methyl]-, hydrochloride; 3-(2-Nitrophenoxymethyl)pyrrolidine HCl; 1220016-33-0; (2-Nitrophenoxy)methylpyrrolidine hydrochloride
EINECS	Contact for details

Quality Control

Our 3-[(2-Nitrophenoxy)Methyl]Pyrrolidinehydrochloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and residual solvent analysis. We provide full traceability and Certificates of Analysis (COA) are available for all shipments, ensuring compliance with the stringent requirements of pharmaceutical R&D and cGMP guidelines where applicable.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and light-sensitive; therefore, containers must be kept sealed and desiccated when not in use to maintain stability and purity.

Specification

Item	Specification
Appearance	Off-white to light yellow crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.