Description

3-[(2,6-Difluorobenzyl)Oxy]Pyrrolidinehydrochloride is a high-purity, advanced pharmaceutical intermediate with the CAS registry number 1219979-20-0. This compound is a critical building block in modern medicinal chemistry, valued for its role in constructing complex molecular architectures. It is primarily sought after by research institutions and pharmaceutical manufacturers engaged in the development of novel active pharmaceutical ingredients (APIs), particularly within therapeutic areas requiring sophisticated fluorine-containing scaffolds.

Application

• Pharmaceutical Intermediate: A key synthon in the research and commercial synthesis of novel drug candidates, especially those targeting central nervous system (CNS) disorders and other therapeutic areas.
• Medicinal Chemistry Research: Used extensively in lead optimization and structure-activity relationship (SAR) studies to improve pharmacokinetic properties and binding affinity.
• API Development: Serves as a crucial precursor in the multi-step synthesis of complex Active Pharmaceutical Ingredients (APIs) that incorporate a pyrrolidine moiety.
• Fluorinated Compound Synthesis: Exploited for the introduction of the difluorobenzyl group, which can enhance metabolic stability, membrane permeability, and bioavailability in drug molecules.
• Contract Research & Manufacturing (CRO/CMO): Supplied to organizations providing custom synthesis and process development services for the global pharmaceutical industry.
• Bioconjugation & Probe Development: Potential use in the development of biochemical probes and labeled compounds for diagnostic and research applications.

Basic Information

Product Name	3-[(2,6-Difluorobenzyl)Oxy]Pyrrolidinehydrochloride
CAS No.	1219979-20-0
Molecular Formula	C11H14F2NO•HCl
Molecular Weight	249.69 g/mol (Free base)
Synonyms	3-[(2,6-Difluorophenyl)methoxy]pyrrolidine hydrochloride; Pyrrolidine, 3-[(2,6-difluorobenzyl)oxy]-, hydrochloride; 3-(2,6-Difluorobenzyloxy)pyrrolidine HCl; 1219979-20-0; UNII-7V3S4A6QNV; 7V3S4A6QNV; 3-((2,6-Difluorobenzyl)oxy)pyrrolidine hydrochloride
EINECS	Contact for details

Quality Control

Our 3-[(2,6-Difluorobenzyl)Oxy]Pyrrolidinehydrochloride is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via NMR and mass spectrometry, to ensure it meets the high standards required for pharmaceutical R&D and cGMP manufacturing. A comprehensive Certificate of Analysis (COA) detailing all specifications and test results is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under inert conditions (e.g., nitrogen atmosphere) after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.