Description

3-{[2-(Trifluoromethyl)Phenoxy]Methyl}Piperidinehydrochloride is a high-value, organofluorine building block and pharmaceutical intermediate. Its core value proposition lies in its unique trifluoromethylphenoxy-piperidine scaffold, which is critical for modulating the biological activity and physicochemical properties of advanced drug candidates. This compound is essential for research and development chemists in the pharmaceutical and agrochemical industries, particularly those focused on creating novel small-molecule therapeutics and crop protection agents.

Application

• Pharmaceutical Intermediate: Serves as a key synthon in the synthesis of active pharmaceutical ingredients (APIs), especially for central nervous system (CNS) and metabolic disorder targets.
• Agrochemical Research: Used in the development of new-generation herbicides, fungicides, and insecticides, where the trifluoromethyl group enhances lipophilicity and metabolic stability.
• Chemical Biology & Proteomics: Employed as a molecular scaffold or linker in the design of chemical probes and activity-based protein profiling (ABPP) reagents.
• Material Science Precursor: Acts as a starting material for synthesizing specialty monomers or ligands used in advanced polymeric materials and catalysts.
• Medicinal Chemistry R&D: A versatile building block for constructing compound libraries via parallel and combinatorial synthesis for high-throughput screening (HTS) campaigns.

Basic Information

Product Name	3-{[2-(Trifluoromethyl)Phenoxy]Methyl}Piperidinehydrochloride
CAS No.	1219960-58-3
Molecular Formula	C14H17ClF3NO
Molecular Weight	307.74 g/mol
Synonyms	3-[(2-Trifluoromethylphenoxy)methyl]piperidine hydrochloride; 3-({[2-(Trifluoromethyl)phenyl]oxy}methyl)piperidine hydrochloride; 1-(2-(Trifluoromethyl)phenoxymethyl)-3-piperidine hydrochloride; Piperidine, 3-[[[2-(trifluoromethyl)phenyl]oxy]methyl]-, hydrochloride (1:1); 1219960-58-3
EINECS	Contact for details

Quality Control

Our 3-{[2-(Trifluoromethyl)Phenoxy]Methyl}Piperidinehydrochloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure high chemical purity and identity confirmation. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specified parameters. Our quality commitment supports applications requiring GMP-grade intermediates and materials for regulatory filings.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.