Description

n-[2-[[(1,1-Dimethylethyl)dimethylsilyl]oxy]ethyl]-2-fluoro-4-nitro-benzenamine is a high-purity, advanced pharmaceutical intermediate designed for the synthesis of complex active pharmaceutical ingredients (APIs). This compound is valued for its role in introducing specific functional groups, particularly the silyl-protected amine and fluoro-nitro aromatic system, which are crucial in modern medicinal chemistry. It is primarily utilized by research institutions and pharmaceutical manufacturers engaged in the development of novel therapeutic agents, especially within oncology and targeted drug discovery programs.

Application

• Pharmaceutical Intermediate: A key building block in the multi-step synthesis of complex drug candidates and active pharmaceutical ingredients (APIs).
• Proteolysis-Targeting Chimera (PROTAC) Development: Used in the construction of linker molecules or warhead components for targeted protein degradation therapeutics.
• Kinase Inhibitor Synthesis: Serves as a precursor in the manufacture of small molecule inhibitors targeting specific kinase pathways.
• Fluorinated Compound Research: Provides a fluorinated aromatic scaffold for structure-activity relationship (SAR) studies in medicinal chemistry.
• Chemical Biology Probes: Employed in the creation of labeled or tagged molecules for studying biological mechanisms and target engagement.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects requiring high-purity, specialized intermediates.

Basic Information

Product Name	n-[2-[[(1,1-Dimethylethyl)dimethylsilyl]oxy]ethyl]-2-fluoro-4-nitro-benzenamine
CAS No.	1219708-11-8
Molecular Formula	C15H25FN2O3Si
Molecular Weight	328.46 g/mol
Synonyms	2-Fluoro-N-[2-[(tert-butyldimethylsilyl)oxy]ethyl]-4-nitroaniline; N-[2-[(tert-Butyldimethylsilyl)oxy]ethyl]-2-fluoro-4-nitroaniline; 2-Fluoro-4-nitro-N-(2-((tert-butyldimethylsilyl)oxy)ethyl)aniline; TBDMS-protected fluoro-nitro aniline derivative; 1219708-11-8; tert-Butyl[2-[(2-fluoro-4-nitrophenyl)amino]ethoxy]dimethylsilane
EINECS	Contact for details

Quality Control

Our n-[2-[[(1,1-Dimethylethyl)dimethylsilyl]oxy]ethyl]-2-fluoro-4-nitro-benzenamine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical quality attributes. Our production adheres to cGMP principles where applicable, ensuring the material meets the stringent requirements for pharmaceutical R&D and pre-clinical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) when appropriate to prevent degradation. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	Yellow to orange crystalline powder or solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.