Description

D-Proline, 3-(3-Chloro-2-Fluorophenyl)-4-(4-Chloro-2-Fluorophenyl)-4-Cyano-5-(2,2-Dimethylpropyl)-, 1,1-Dimethylethyl Ester, (3S,4R,5S)-Rel- is a high-purity, non-natural amino acid derivative designed for advanced pharmaceutical research and development. This chiral building block is critical for the synthesis of complex molecules, offering researchers precise stereochemical control. It is primarily utilized by medicinal chemists and process development scientists in the pharmaceutical and biotechnology industries for creating novel therapeutic candidates, particularly in targeted drug discovery programs.

Application

• Pharmaceutical Intermediate: Serves as a key chiral synthon in the research and development of new active pharmaceutical ingredients (APIs).
• Medicinal Chemistry: Used in structure-activity relationship (SAR) studies and lead optimization for drug discovery projects.
• Process Chemistry: Employed in route scouting and scale-up synthesis for the manufacture of investigational drugs.
• Peptidomimetics: Acts as a constrained proline analog for designing and synthesizing novel peptide-based therapeutics.
• Chemical Biology: Utilized as a molecular probe to study enzyme mechanisms or protein-protein interactions.
• Asymmetric Synthesis: Functions as a chiral auxiliary or precursor in stereoselective chemical transformations.

Basic Information

Product Name	D-Proline, 3-(3-Chloro-2-Fluorophenyl)-4-(4-Chloro-2-Fluorophenyl)-4-Cyano-5-(2,2-Dimethylpropyl)-, 1,1-Dimethylethyl Ester, (3S,4R,5S)-Rel-
CAS No.	1219086-88-0
Molecular Formula	C29H32Cl2F2N2O2
Molecular Weight	545.48 g/mol
Synonyms	(3S,4R,5S)-rel-3-(3-Chloro-2-fluorophenyl)-4-(4-chloro-2-fluorophenyl)-4-cyano-5-(2,2-dimethylpropyl)-1,1-dimethylethyl pyrrolidine-2-carboxylate; tert-Butyl (3S,4R,5S)-rel-3-(3-chloro-2-fluorophenyl)-4-(4-chloro-2-fluorophenyl)-4-cyano-5-neopentyl-D-prolinate; D-Proline derivative CAS 1219086-88-0; rel-(3S,4R,5S)-tert-Butyl 3-(3-chloro-2-fluorophenyl)-4-(4-chloro-2-fluorophenyl)-4-cyano-5-neopentylpyrrolidine-2-carboxylate; Advanced Pharmaceutical Intermediate 1219086-88-0; Chiral Fluorinated Proline Ester
EINECS	Contact for details

Quality Control

This product is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high chemical purity suitable for research applications. Quality is verified through comprehensive analytical techniques including HPLC, NMR, and mass spectrometry. A Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with each batch to support your regulatory and research documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Specific Rotation	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.