Description

5,6,7,8-Tetrahydro-1,5-Naphthyridine-2-Carbonitrile is a high-purity, advanced pharmaceutical intermediate with the CAS registry number 1219022-67-9. This heterocyclic nitrile compound is a critical building block in modern medicinal chemistry, valued for its unique fused ring structure that enables the synthesis of complex bioactive molecules. It is primarily sought by research institutions and pharmaceutical manufacturers engaged in the development of novel therapeutic agents, particularly within oncology and central nervous system (CNS) drug discovery pipelines.

Application

• Pharmaceutical Intermediate: A key precursor in the multi-step synthesis of active pharmaceutical ingredients (APIs) for investigational new drugs.
• Medicinal Chemistry Research: Serves as a versatile scaffold for constructing compound libraries in high-throughput screening and structure-activity relationship (SAR) studies.
• Kinase Inhibitor Development: The naphthyridine core is integral to designing potent and selective inhibitors for various kinase targets implicated in cancer.
• CNS Drug Candidates: Used in the research and development of potential therapeutics for neurological disorders.
• Contract Research & Manufacturing (CRO/CMO): Supplied to service organizations supporting pharmaceutical R&D and scale-up activities.
• Academic Research: Utilized in university and institutional labs for fundamental studies in organic synthesis and heterocyclic chemistry.

Basic Information

Product Name	5,6,7,8-Tetrahydro-1,5-Naphthyridine-2-Carbonitrile
CAS No.	1219022-67-9
Molecular Formula	C9H9N3
Molecular Weight	159.19 g/mol
Synonyms	1,2,3,4-Tetrahydro-1,5-naphthyridine-2-carbonitrile; 1,5-Naphthyridine-2-carbonitrile, 1,2,3,4-tetrahydro-; 2-Cyano-1,2,3,4-tetrahydro-1,5-naphthyridine; 5,6,7,8-Tetrahydro-1,5-naphthyridine-2-carbonitrile; THN-2-CN; 1,5-Naphthyridine-2-carbonitrile, tetrahydro-
EINECS	Contact for details

Quality Control

We supply 5,6,7,8-Tetrahydro-1,5-Naphthyridine-2-Carbonitrile in high-purity grades suitable for research and development. Our products undergo rigorous quality testing to ensure compliance with industry standards. Certificates of Analysis (COA) are available upon request, detailing purity, identity, and impurity profiles as confirmed by advanced analytical techniques.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (15-25°C). Keep away from incompatible materials. For long-term storage, consider an inert atmosphere to maintain optimal stability.

Specification

Item	Specification
Appearance	White to off-white powder or crystalline solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Related Substances (HPLC)	Total impurities ≤ 3.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.