Description

Cyclobutanol, 3-Amino-, Hydrochloride (1:1), cis- is a high-purity, stereochemically defined organic building block. This compound is valued for its rigid cyclobutane scaffold and functional amine group, making it a critical intermediate in advanced pharmaceutical synthesis and materials science research. It is primarily sought by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries for constructing novel molecular architectures.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of novel active pharmaceutical ingredients (APIs), particularly in medicinal chemistry programs targeting central nervous system (CNS) disorders and anti-infectives.
• Agrochemical Research: Used in the development of new herbicides and pesticides, where the strained cyclobutane ring can impart unique biological activity and metabolic stability.
• Ligand & Catalyst Development: Serves as a precursor for chiral ligands and organocatalysts in asymmetric synthesis, leveraging its defined cis-stereochemistry.
• Peptidomimetics & Conformationally Restricted Analogs: Incorporated into peptide backbones to induce specific conformational constraints, enhancing binding affinity and proteolytic stability.
• Material Science Monomer: Potential monomer for creating polymers with unique thermal and mechanical properties derived from the rigid, four-membered ring structure.
• Chemical Biology Probe Synthesis: Utilized in the construction of molecular probes and tags for studying biological systems and target engagement.

Basic Information

Product Name	Cyclobutanol, 3-Amino-, Hydrochloride (1:1), cis-
CAS No.	1219019-22-3
Molecular Formula	C4H9NO • HCl
Molecular Weight	123.58 g/mol
Synonyms	cis-3-Aminocyclobutanol Hydrochloride; (1r,3r)-3-Aminocyclobutanol Hydrochloride; (1s,3s)-3-Aminocyclobutanol Hydrochloride; 3-Amino-cis-cyclobutanol HCl; 3-Aminocyclobutanol Hydrochloride, cis-; Aminocyclobutanol Hydrochloride; Cyclobutanol, 3-amino-, hydrochloride, cis-
EINECS	Contact for details

Quality Control

Every batch of cis-3-Aminocyclobutanol Hydrochloride is manufactured under a strict quality management system and undergoes comprehensive analytical testing to ensure identity, purity, and consistency. Our standard grade meets high-purity research and development requirements, with Certificates of Analysis (COA) providing full traceability and documentation of critical parameters such as assay, enantiomeric excess, and impurity profiles. We support development with custom synthesis and scale-up capabilities under cGMP guidelines as needed.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Purity (HPLC, Area%)	≥ 99.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Specific Rotation	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.