Description

(R)-1-((R)-tert-Butylsulfinyl)-2-(4-Fluorophenyl)Pyrrolidine is a high-purity chiral sulfinamide building block of significant importance in asymmetric synthesis. This compound serves as a critical intermediate for constructing complex molecules with defined stereochemistry, enabling the development of novel pharmaceuticals and agrochemicals. It is primarily required by research institutions and process development chemists in the pharmaceutical industry for the synthesis of active pharmaceutical ingredients (APIs) and other fine chemicals.

Application

• Pharmaceutical Intermediate: A key chiral auxiliary and building block in the asymmetric synthesis of complex drug candidates, particularly those targeting central nervous system (CNS) disorders.
• Agrochemical Research: Used in the development of enantiomerically pure pesticides and herbicides, where specific stereochemistry is crucial for bioactivity and environmental safety.
• Catalyst Ligand Precursor: Acts as a precursor for chiral ligands used in transition metal catalysis to induce stereoselectivity in various organic transformations.
• Academic & Process Chemistry: Employed in research laboratories for methodological development in stereoselective synthesis and scale-up process optimization.
• Fine Chemical Synthesis: Utilized in the production of other high-value, specialty chemicals requiring the introduction of a fluorinated phenylpyrrolidine moiety with precise stereocontrol.

Basic Information

Product Name	(R)-1-((R)-tert-Butylsulfinyl)-2-(4-Fluorophenyl)Pyrrolidine
CAS No.	1218989-47-9
Molecular Formula	C15H22FNO2S
Molecular Weight	299.41 g/mol
Synonyms	(R,R)-1-(tert-Butylsulfinyl)-2-(4-fluorophenyl)pyrrolidine; (R)-2-(4-Fluorophenyl)-1-[(R)-tert-butylsulfinyl]pyrrolidine; tert-Butanesulfinamide, N-[(2R)-2-(4-fluorophenyl)-1-pyrrolidinyl]-, (R)-; (R)-N-((R)-2-(4-Fluorophenyl)pyrrolidin-1-yl)-2-methylpropane-2-sulfinamide; (R,R)-tert-Butylsulfinyl-2-(4-fluorophenyl)pyrrolidine; Chiral Sulfinamide Derivative; (R,R)-Sulfinyl Pyrrolidine Fluorophenyl Derivative
EINECS	Contact for details

Quality Control

Our (R)-1-((R)-tert-Butylsulfinyl)-2-(4-Fluorophenyl)Pyrrolidine is manufactured under strict quality control protocols to ensure high chemical and chiral purity, essential for sensitive asymmetric synthesis. Production adheres to cGMP guidelines where applicable, and each batch is supported by a comprehensive Certificate of Analysis (COA). The COA includes data for chiral purity (enantiomeric excess), chemical purity (HPLC), identity confirmation (NMR, IR), and impurity profiling.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) when opening the container for use to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% e.e.
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.