Description

(S)-α-Propynyl-Proline-Hcl CAS NO 1217828-88-0 is a high-purity, non-natural amino acid derivative featuring a proline backbone modified with a propynyl group at the alpha position. This compound is a critical chiral building block and intermediate in modern pharmaceutical research and development, enabling the synthesis of complex, biologically active molecules. It is primarily utilized by medicinal chemists and process development scientists in the pharmaceutical and biotechnology industries for the creation of novel drug candidates, particularly in peptide mimetics and protease inhibitor programs.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the synthesis of active pharmaceutical ingredients (APIs) targeting various disease pathways.
• Peptidomimetic Drug Discovery: Used to introduce conformational constraints and novel functionality into peptide-based drug candidates, enhancing metabolic stability and binding affinity.
• Protease Inhibitor Development: Serves as a core scaffold in the design of inhibitors for enzymes like kinases, caspases, and other proteases.
• Chemical Biology & Bioconjugation: The alkyne (propynyl) group allows for site-specific modification via click chemistry (e.g., CuAAC) for labeling, probing, or linker attachment.
• Asymmetric Synthesis: Employed as a chiral auxiliary or ligand in catalytic asymmetric reactions to induce stereoselectivity.
• Academic & Contract Research: Used in university and CRO laboratories for fundamental research in organic chemistry and medicinal chemistry.

Basic Information

Product Name	(S)-α-Propynyl-Proline-Hcl
CAS No.	1217828-88-0
Molecular Formula	C8H12ClNO2
Molecular Weight	189.64 g/mol
Synonyms	(S)-2-Propynylproline hydrochloride; (S)-1-(Prop-2-yn-1-yl)pyrrolidine-2-carboxylic acid hydrochloride; L-Proline, 1-(2-propyn-1-yl)-, hydrochloride (1:1); (S)-α-Propynylproline HCl; Propynyl-L-proline hydrochloride; 1-Propargyl-L-proline hydrochloride; (S)-1-Propargylproline hydrochloride
EINECS	Contact for details

Quality Control

Every batch of (S)-α-Propynyl-Proline-Hcl is manufactured under strict quality management systems. We provide comprehensive analytical documentation to ensure product identity, purity, and consistency for your critical research and development applications. Certificates of Analysis (COA) detailing purity (typically ≥98% by HPLC), chiral purity, and impurity profiles are available for each lot upon request. Our quality commitment supports compliance with cGMP guidelines for pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); keep the container tightly sealed in a dry environment to prevent degradation. For long-term storage, consider desiccants or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.