Description

Butyl 6,8-Difluoro-4-((4Ar,8As)-Octahydroisoquinolin-2(1H)-Yl)Quinoline-2-Carboxylate is a high-purity, advanced pharmaceutical intermediate designed for the synthesis of complex active pharmaceutical ingredients (APIs). This compound is critical for research and development in medicinal chemistry, offering a sophisticated molecular scaffold for creating novel therapeutic agents. It is primarily utilized by pharmaceutical manufacturers, contract research organizations (CROs), and academic research institutions focused on drug discovery, particularly in areas requiring fluorinated quinoline derivatives.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of novel drug candidates, especially in oncology and central nervous system (CNS) therapeutic areas.
• Medicinal Chemistry Research: Used as a core scaffold for structure-activity relationship (SAR) studies and lead optimization in drug discovery programs.
• Fluorinated Compound Synthesis: Serves as a precursor for developing other complex fluorinated molecules, leveraging the properties of fluorine in drug design.
• API Development: Integral in the process development and scale-up stages for new active pharmaceutical ingredients.
• Biochemical Research: Potential tool compound for investigating biological pathways and target validation in vitro.

Basic Information

Item	Detail
Product Name	Butyl 6,8-Difluoro-4-((4Ar,8As)-Octahydroisoquinolin-2(1H)-Yl)Quinoline-2-Carboxylate
CAS No.	1217817-81-6
Molecular Formula	C23H28F2N2O2
Molecular Weight	402.48 g/mol
Synonyms	6,8-Difluoro-4-((4aR,8aS)-octahydroisoquinolin-2(1H)-yl)quinoline-2-carboxylic acid butyl ester; Butyl 6,8-difluoro-4-(octahydro-2(1H)-isoquinolinyl)-2-quinolinecarboxylate; (4aR,8aS)-2-(6,8-Difluoro-2-(butoxycarbonyl)quinolin-4-yl)octahydroisoquinoline; 1217817-81-6; Fluorinated Quinoline Isoquinoline Derivative; B6,8DF4OIQ2C
EINECS	Contact for details

Quality Control

Our Butyl 6,8-Difluoro-4-((4Ar,8As)-Octahydroisoquinolin-2(1H)-Yl)Quinoline-2-Carboxylate is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. A Certificate of Analysis (COA) detailing all specifications is provided with each shipment. We adhere to cGMP guidelines where applicable to support our clients' regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to exclude moisture. For long-term storage, consider using desiccants or storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (IR)	Conforms
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.