Description

Methyl (3R)-3-Amino-3-(4-Fluorophenyl)Propanoate Hydrochloride is a high-purity chiral building block and pharmaceutical intermediate. This compound is critical for the synthesis of active pharmaceutical ingredients (APIs) requiring a specific stereochemical configuration. It is primarily needed by research institutions and manufacturers in the pharmaceutical and fine chemical industries for developing new therapeutic agents.

Application

• Pharmaceutical Intermediate: Key chiral synthon for the research and production of novel drug candidates, particularly in central nervous system (CNS) and psychiatric therapeutic areas.
• API Synthesis: Used in the multi-step synthesis of complex Active Pharmaceutical Ingredients (APIs) that incorporate a fluorinated phenylalanine derivative moiety.
• Asymmetric Synthesis: Serves as a valuable starting material or reagent in asymmetric catalytic processes and chiral pool synthesis.
• Medicinal Chemistry Research: Employed in structure-activity relationship (SAR) studies and lead optimization during early-stage drug discovery.
• Process Chemistry Development: Utilized for scaling up synthetic routes from laboratory to pilot plant and commercial manufacturing scales.
• Reference Standard: Can be supplied as a high-purity analytical standard for quality control and method development in regulatory filings.

Basic Information

Product Name	Methyl (3R)-3-Amino-3-(4-Fluorophenyl)Propanoate Hydrochloride
CAS No.	1217792-89-6
Molecular Formula	C10H13FNO2 • HCl
Molecular Weight	233.67 g/mol (Free base: 197.22 g/mol)
Synonyms	(R)-Methyl 3-amino-3-(4-fluorophenyl)propanoate hydrochloride; Methyl (R)-3-amino-3-(4-fluorophenyl)propionate HCl; (3R)-3-Amino-3-(4-fluorophenyl)propanoic acid methyl ester hydrochloride; (R)-3-Amino-3-(4-fluorophenyl)propionic acid methyl ester hydrochloride; 4-Fluoro-D-homophenylalanine methyl ester hydrochloride; D-4-Fluorohomophenylalanine methyl ester hydrochloride; (R)-Methyl 3-amino-3-(p-fluorophenyl)propanoate hydrochloride
EINECS	Contact for details

Quality Control

Our Methyl (3R)-3-Amino-3-(4-Fluorophenyl)Propanoate Hydrochloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity verification by HPLC, to ensure compliance with pharmaceutical-grade standards. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to support your regulatory and quality assurance requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under anhydrous conditions. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% ee
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm
Single Unknown Impurity (HPLC)	≤0.5%
Total Impurities (HPLC)	≤2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.