Description

(2R,3R)-3-Amino-2-Hydroxy-3-(3-Methoxy-Phenyl)-Propionic Acid CAS NO 1217790-42-5 is a high-purity, non-natural amino acid derivative featuring a chiral β-hydroxy-α-amino acid scaffold with a 3-methoxyphenyl substituent. This compound is a critical chiral building block and intermediate in the synthesis of complex pharmaceutical molecules, particularly for developing protease inhibitors and other bioactive agents. It is essential for research and production in pharmaceutical chemistry, medicinal chemistry, and advanced organic synthesis, where precise stereochemistry and high purity are paramount for successful outcomes.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the research and development of new active pharmaceutical ingredients (APIs), especially protease inhibitors.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and as a building block for creating novel compound libraries targeting various diseases.
• Peptidomimetics: Serves as a constrained amino acid analog for designing and synthesizing peptide mimics with enhanced metabolic stability and bioavailability.
• Asymmetric Synthesis: Employed as a chiral auxiliary or starting material in stereoselective chemical reactions to introduce defined stereocenters.
• Biochemical Research: Utilized in studying enzyme-substrate interactions and mechanisms due to its specific stereochemistry and functional groups.
• Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects under cGMP conditions.

Basic Information

Product Name	(2R,3R)-3-Amino-2-Hydroxy-3-(3-Methoxy-Phenyl)-Propionic Acid
CAS No.	1217790-42-5
Molecular Formula	C10H13NO4
Molecular Weight	211.22 g/mol
Synonyms	(2R,3R)-3-Amino-2-hydroxy-3-(3-methoxyphenyl)propanoic acid; D-erythro-3-Amino-2-hydroxy-3-(3-methoxyphenyl)propionic acid; β-Hydroxy-3-methoxy-D-phenylalanine; (2R,3R)-AHMPA; (2R,3R)-3-Amino-2-hydroxy-3-(3-methoxyphenyl)propionic Acid; 3-Methoxy-D-erythro-β-hydroxy-phenylalanine; A chiral β-hydroxy-α-amino acid derivative
EINECS	Contact for details

Quality Control

Our (2R,3R)-3-Amino-2-Hydroxy-3-(3-Methoxy-Phenyl)-Propionic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral HPLC for enantiomeric excess (ee) and standard purity assays, to ensure compliance with stringent specifications for pharmaceutical R&D use. Certificates of Analysis (COA) detailing identity, purity, chiral purity, and impurity profiles are provided with every shipment and are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under dry, inert conditions to prevent degradation. For long-term storage, consider storing under an inert atmosphere such as argon or nitrogen.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.