Description

n-Boc-(2R,3R)-3-Amino-2-Hydroxy-3-(4-Trifluoromethyl-Phenyl)-Propionic Acid is a high-purity, non-natural amino acid derivative featuring a chiral β-hydroxy-α-amino acid scaffold protected by a tert-butoxycarbonyl (Boc) group. This compound is a critical chiral building block for the synthesis of complex bioactive molecules, offering precise stereochemical control. It is primarily utilized by pharmaceutical R&D and process chemistry teams in the development of novel therapeutics, including protease inhibitors and other targeted agents.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the research and development of new active pharmaceutical ingredients (APIs), particularly in antiviral and anticancer drug candidates.
• Peptidomimetics Synthesis: Used to incorporate a constrained, trifluoromethyl-phenyl substituted amino acid moiety into peptide backbones to enhance metabolic stability and binding affinity.
• Protease Inhibitor Development: Serves as a core structural element in the design of inhibitors for various protease enzymes due to its hydroxychylamine transition-state isostere motif.
• Chemical Biology & Probe Design: Employed in the creation of labeled or tagged chemical probes for studying enzyme function and biological pathways.
• Process Chemistry & Scale-Up: Supplied under cGMP-compatible conditions for use in late-stage preclinical and clinical manufacturing campaigns.
• Academic Research: Used in university and institutional labs for methodological studies in asymmetric synthesis and medicinal chemistry.

Basic Information

Product Name	n-Boc-(2R,3R)-3-Amino-2-Hydroxy-3-(4-Trifluoromethyl-Phenyl)-Propionic Acid
CAS No.	1217733-31-7
Molecular Formula	C15H18F3NO5
Molecular Weight	349.31 g/mol
Synonyms	(2R,3R)-3-[(tert-Butoxycarbonyl)amino]-2-hydroxy-3-[4-(trifluoromethyl)phenyl]propanoic Acid; (2R,3R)-N-Boc-3-Amino-2-hydroxy-3-(4-trifluoromethylphenyl)propionic Acid; Boc-(2R,3R)-AHPTPA; (2R,3R)-Boc-AHPTPA; tert-Butyl (1R,2R)-1-(carboxymethyl)-2-hydroxy-2-[4-(trifluoromethyl)phenyl]ethylcarbamate; (2R,3R)-3-(Boc-amino)-2-hydroxy-3-(4-trifluoromethylphenyl)propanoic Acid
EINECS	Contact for details

Quality Control

Our n-Boc-(2R,3R)-3-Amino-2-Hydroxy-3-(4-Trifluoromethyl-Phenyl)-Propionic Acid is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral HPLC for enantiomeric excess and NMR for structural confirmation, to ensure high chemical and chiral purity suitable for demanding pharmaceutical applications. Certificates of Analysis (COA) with detailed chromatographic data are provided for every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C for long-term stability. This compound is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain purity. Allow the sealed container to equilibrate to room temperature before opening to prevent moisture condensation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.