Description

(R)-2-(n-Fmoc-Aminomethyl)Pyrrolidine Hcl is a high-purity, chiral building block and Fmoc-protected amino acid derivative essential for advanced organic synthesis. This compound is critical for the controlled introduction of a pyrrolidine scaffold with a primary amine handle, enabling the synthesis of complex, stereochemically defined molecules. It is primarily required by research institutions and pharmaceutical companies engaged in peptide mimetic development, medicinal chemistry, and the synthesis of novel bioactive compounds targeting a global market.

Application

• Solid-Phase Peptide Synthesis (SPPS): As an Fmoc-protected amino acid derivative for the controlled incorporation of a constrained, chiral pyrrolidine moiety into peptide chains.
• Medicinal Chemistry & Drug Discovery: A key chiral intermediate for constructing pharmacologically active scaffolds, including protease inhibitors and GPCR ligands.
• Peptidomimetic Design: Used to create non-natural peptide analogs with enhanced metabolic stability and binding affinity by replacing standard amino acids.
• Chemical Biology Probes: Synthesis of tagged or labeled compounds for studying enzyme-substrate interactions and biological pathways.
• Asymmetric Synthesis: Serves as a chiral auxiliary or building block in the synthesis of enantiomerically pure natural products and fine chemicals.
• Library Synthesis for High-Throughput Screening: Generation of diverse compound libraries focused on nitrogen-containing heterocycles for biological evaluation.

Basic Information

Product Name	(R)-2-(n-Fmoc-Aminomethyl)Pyrrolidine Hydrochloride
CAS No.	1217730-75-0
Molecular Formula	C₂₁H₂₄N₂O₂·HCl
Molecular Weight	372.89 g/mol (Free base: 336.43 g/mol)
Synonyms	Fmoc-(R)-Amp(Pyr)-OH·HCl; (R)-2-[(9H-Fluoren-9-ylmethoxy)carbonylaminomethyl]pyrrolidine hydrochloride; N-α-Fmoc-(R)-2-Aminomethylpyrrolidine hydrochloride; (R)-N-Fmoc-2-(Aminomethyl)pyrrolidine HCl; Fmoc-D-Amp(Pyr)-OH·HCl; 1-[(9H-Fluoren-9-ylmethoxy)carbonylamino]methyl-(R)-pyrrolidine hydrochloride; (R)-1-(Fmoc-aminomethyl)pyrrolidine hydrochloride
EINECS	Contact for details

Quality Control

Our (R)-2-(n-Fmoc-Aminomethyl)Pyrrolidine Hcl is manufactured under strict quality systems to ensure high chemical and chiral purity suitable for research and pharmaceutical development. Each batch is supported by a comprehensive Certificate of Analysis (COA) detailing purity, chiral integrity, and impurity profiles. We adhere to relevant industry standards, and specifications can be tailored to meet specific project requirements upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C (refrigerated) or as specified on the label or COA. This material is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity. Allow the sealed container to reach room temperature before opening to prevent moisture condensation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Chiral Purity (Chiral HPLC)	≥99.0% ee
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.