Description

(S)-α-(4-Biphenylmethyl)-Proline-Hcl CAS NO 1217722-65-0 is a high-purity, non-natural amino acid derivative featuring a chiral proline core modified with a biphenylmethyl group. This compound is a critical chiral building block and intermediate in modern pharmaceutical research and development, enabling the synthesis of complex, biologically active molecules. It is primarily utilized by research institutions and pharmaceutical companies engaged in the discovery and development of new therapeutic agents, particularly in the areas of protease inhibitors and other small-molecule drugs.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the synthesis of novel drug candidates, especially protease inhibitors.
• Peptidomimetics Research: Used to construct constrained peptide analogs to enhance metabolic stability and bioavailability.
• Asymmetric Synthesis: Serves as a chiral auxiliary or catalyst component in stereoselective chemical transformations.
• Medicinal Chemistry: Employed in structure-activity relationship (SAR) studies to optimize lead compounds.
• Bioconjugation: Potential use in creating targeted drug delivery systems or diagnostic probes.
• Chemical Biology: Useful as a tool compound for probing enzyme active sites or protein-protein interactions.

Basic Information

Product Name	(S)-α-(4-Biphenylmethyl)-Proline Hydrochloride
CAS No.	1217722-65-0
Molecular Formula	C22H23NO2·HCl
Molecular Weight	369.89 g/mol
Synonyms	(S)-α-(4-Biphenylmethyl)proline hydrochloride; (S)-2-[(1,1'-Biphenyl]-4-ylmethyl)pyrrolidine-2-carboxylic acid hydrochloride; (S)-4-Biphenylmethyl-proline HCl; (S)-BPMP-HCl; (S)-2-[(4-Phenylbenzyl)amino]-5-oxopentanoic acid hydrochloride (tautomeric form); L-α-(4-Biphenylmethyl)proline hydrochloride; (2S)-2-[(4-Phenylphenyl)methyl]pyrrolidine-2-carboxylic acid hydrochloride
EINECS	Contact for details

Quality Control

Our (S)-α-(4-Biphenylmethyl)-Proline-Hcl is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification by HPLC, to ensure it meets the high standards required for pharmaceutical research. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are provided with every shipment and are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to prevent moisture absorption, which can affect stability and purity. For long-term storage, consider desiccants or an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% ee
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.