Description

R-2-Cbz-Aminomethyl-Piperidine-Hcl is a protected piperidine derivative, a high-purity building block essential for advanced organic synthesis. Its primary value lies in serving as a key chiral intermediate for constructing complex molecules in pharmaceutical research and development. This compound is critically needed by medicinal chemists and process development scientists in the pharmaceutical, agrochemical, and fine chemical industries for the synthesis of active pharmaceutical ingredients (APIs) and other bioactive compounds.

Application

• Pharmaceutical Intermediate: A crucial chiral building block for the synthesis of novel drug candidates, particularly in central nervous system (CNS) and metabolic disorder research.
• Peptidomimetic Synthesis: Used to introduce constrained piperidine scaffolds into peptide backbones to enhance metabolic stability and bioavailability.
• Ligand and Catalyst Development: Serves as a precursor for chiral ligands and organocatalysts used in asymmetric synthesis.
• Agrochemical Research: Employed in the development of new pesticides and herbicides where specific stereochemistry is required for activity.
• Academic & R&D Laboratories: A valuable reagent for methodological studies in organic chemistry and medicinal chemistry programs.
• Custom Synthesis: A starting material for contract research organizations (CROs) and CDMOs producing bespoke compounds for client projects.

Basic Information

Product Name	R-2-Cbz-Aminomethyl-Piperidine-Hcl
CAS No.	1217680-53-9
Molecular Formula	C15H22N2O2 • HCl
Molecular Weight	298.81 g/mol
Synonyms	(R)-1-(((Benzyloxy)carbonyl)amino)methyl)piperidine-2-carboxylic acid hydrochloride; (R)-1-((((Cbz)amino)methyl)piperidine-2-carboxylic acid hydrochloride; (R)-N-((Piperidin-2-yl)methyl)carbamic acid benzyl ester hydrochloride; (R)-2-Carbobenzyloxyaminomethylpiperidine hydrochloride; (R)-Cbz-Aminomethyl-Piperidine-HCl; (R)-Cbz-AMP-HCl; (R)-N-Cbz-2-aminomethylpiperidine hydrochloride
EINECS	Contact for details

Quality Control

Our R-2-Cbz-Aminomethyl-Piperidine-Hcl is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification by HPLC, to ensure it meets the stringent requirements for pharmaceutical R&D. A detailed Certificate of Analysis (COA) providing batch-specific data for identity, purity, and chiral excess is supplied with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept under inert atmosphere or in a desiccator after opening to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Chiral Purity (Chiral HPLC)	≥99.0% ee
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.