Description

R-2-(Cbz-Aminomethyl)Pyrrolidine-Hcl is a high-purity chiral building block and protected amino acid derivative. This compound is essential for the synthesis of complex molecules, offering a key stereogenic center for constructing peptidomimetics and active pharmaceutical ingredients (APIs). It is primarily used by research institutions and pharmaceutical companies engaged in drug discovery and process development for therapeutic agents.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of novel drug candidates, particularly in oncology and central nervous system (CNS) therapeutic areas.
• Peptidomimetic Synthesis: Serves as a crucial building block for constructing constrained peptide analogs and protease inhibitors.
• Asymmetric Synthesis: Used as a starting material or auxiliary in catalytic asymmetric reactions to introduce chirality into target molecules.
• Chemical Biology Research: Employed in the design and synthesis of molecular probes and tool compounds for studying biological pathways.
• Custom Synthesis & Contract Manufacturing: A critical raw material for CDMOs (Contract Development and Manufacturing Organizations) producing APIs under cGMP standards.

Basic Information

Product Name	R-2-(Cbz-Aminomethyl)Pyrrolidine-Hcl
CAS No.	1217652-74-8
Molecular Formula	C14H20N2O2•HCl
Molecular Weight	284.78 g/mol
Synonyms	(R)-1-((((9H-Fluoren-9-yl)methoxy)carbonyl)aminomethyl)pyrrolidine hydrochloride; (R)-N-(((9H-Fluoren-9-yl)methoxy)carbonyl)-1-(aminomethyl)pyrrolidine hydrochloride; (R)-2-((Fmoc-Aminomethyl))pyrrolidine hydrochloride; (R)-N-Fmoc-2-(aminomethyl)pyrrolidine HCl; (R)-1-((Fmoc-amino)methyl)pyrrolidine hydrochloride; R-2-(Fmoc-aminomethyl)pyrrolidine HCl; (R)-N-α-Fmoc-2-pyrrolidinemethanamine hydrochloride
EINECS	Contact for details

Quality Control

Our R-2-(Cbz-Aminomethyl)Pyrrolidine-Hcl is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and chiral purity, NMR, and MS for structural confirmation, to ensure it meets the stringent requirements for pharmaceutical R&D. Certificates of Analysis (COA) with detailed specifications are provided and can be tailored to support regulatory filings.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This material is hygroscopic (moisture-sensitive) and should be handled under dry conditions to maintain stability and purity. For long-term storage, consider storage under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.