Description

Ethyl (R)-3-(3-Pyridyl)-β-Alanate 2Hcl is a high-purity chiral intermediate, specifically the hydrochloride salt of an ethyl ester derivative of a pyridyl-substituted β-alanine. This compound is critical for ensuring enantiomeric purity in advanced synthetic pathways, directly impacting the efficacy and safety of the final active pharmaceutical ingredient. It is an essential building block for research and development chemists and process scale-up teams within the pharmaceutical and fine chemical industries, particularly for the synthesis of novel therapeutic agents.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and commercial synthesis of active pharmaceutical ingredients (APIs), especially for central nervous system (CNS) and cardiovascular targets.
• Peptidomimetics & Bioactive Molecule Synthesis: Serves as a constrained amino acid analog for constructing peptide-like molecules with enhanced metabolic stability and receptor selectivity.
• Asymmetric Synthesis: Utilized in stereoselective reactions to introduce the (R)-configured chiral center into complex molecular architectures.
• Medicinal Chemistry Research: Employed in lead optimization and structure-activity relationship (SAR) studies to develop new drug candidates.
• Reference Standard: Used as a high-purity analytical standard for method development and quality control in regulatory submissions.
• Chemical Biology Probes: Incorporated into molecular probes for studying enzyme mechanisms and protein-ligand interactions.

Basic Information

Product Name	Ethyl (R)-3-(3-Pyridyl)-β-Alanate 2Hcl
CAS No.	1217631-87-2
Molecular Formula	C10H15Cl2N2O2
Molecular Weight	266.15 g/mol
Synonyms	(R)-Ethyl 3-(pyridin-3-yl)-β-alaninate dihydrochloride; Ethyl (R)-3-(3-pyridinyl)-β-alaninate hydrochloride (1:2); (R)-3-(3-Pyridyl)-β-alanine ethyl ester dihydrochloride; Ethyl (R)-3-(3-Pyridyl)-β-alaninate dihydrochloride; Ethyl (R)-3-(3-Pyridyl)-β-alaninate 2HCl; 3-Pyridinepropanoic acid, β-amino-, ethyl ester, (βR)-, hydrochloride (1:2)
EINECS	Contact for details

Quality Control

Every batch of Ethyl (R)-3-(3-Pyridyl)-β-Alanate 2Hcl is manufactured under a quality management system and undergoes rigorous analytical testing to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing specifications such as chiral purity, assay, and impurity profiles. Our quality commitment supports compliance with cGMP and ICH guidelines for pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept under anhydrous conditions. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Chiral Purity (Chiral HPLC)	≥99.0% ee
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm
Related Substances (HPLC)	Total impurities ≤2.0%; Any single impurity ≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.