Description

Boc-Mehis(Trt)-Oh is a protected amino acid derivative, specifically a histidine analog, designed for advanced peptide synthesis. This compound is critical for researchers and manufacturers requiring precise control over side-chain reactivity during the construction of complex peptide sequences. It is primarily utilized in the pharmaceutical and biotechnology sectors for the development of novel therapeutic peptides, diagnostic agents, and biochemical research tools.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key building block for the controlled incorporation of histidine residues with orthogonal protecting groups.
• Pharmaceutical Intermediates: Used in the research and development of peptide-based drugs targeting various diseases.
• Bioconjugation: Serves as a precursor for creating labeled peptides or peptide-protein conjugates for diagnostic applications.
• Chemical Biology Research: Essential for studying protein-protein interactions, enzyme mechanisms, and signal transduction pathways using synthetic peptide probes.
• Catalyst and Ligand Development: The imidazole side chain, when appropriately deprotected, can be utilized in the design of metal-chelating ligands or organocatalysts.

Basic Information

Product Name	Boc-Mehis(Trt)-Oh
CAS No.	1217610-35-9
Molecular Formula	C31H34N4O4
Molecular Weight	526.63 g/mol
Synonyms	N-α-(tert-Butoxycarbonyl)-N-π-trityl-L-histidine; Boc-His(Trt)-OH; (2S)-2-[(tert-Butoxycarbonyl)amino]-3-[1-(tritylamino)imidazol-4-yl]propanoic acid; Boc-L-Histidine(N-π-Trt)-OH; Fmoc-His(Trt)-OH precursor; Protected Histidine derivative; Peptide synthesis building block
EINECS	Contact for details

Quality Control

Our Boc-Mehis(Trt)-Oh is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity for sensitive synthetic applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, chiral integrity, and impurity profiles. We adhere to relevant industry standards for fine chemical and pharmaceutical intermediate production.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccant and inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC/MS)	Conforms
Purity (HPLC)	≥ 98.0%
Optical Rotation	Contact for details
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.