Description

(S)-2-Azido-3-(3-indolyl)propionic acid cyclohexylammonium salt is a high-purity, non-natural amino acid derivative designed for advanced research and pharmaceutical development. This compound is a critical chiral building block, valued for its unique azide functional group which enables efficient "click chemistry" reactions for bioconjugation and peptide modification. It is essential for medicinal chemists and researchers in biotechnology and pharmaceutical R&D focused on creating novel peptide-based therapeutics, targeted drug delivery systems, and chemical probes.

Application

• Peptide Synthesis: As a specialized, non-proteinogenic amino acid for the solid-phase or solution-phase synthesis of modified peptides with bio-orthogonal handles.
• Bioconjugation & Labeling: The azide group facilitates copper-catalyzed azide-alkyne cycloaddition (CuAAC) for site-specific labeling of proteins, antibodies, or other biomolecules with fluorophores, drugs, or polymers.
• PROTAC & Molecular Glue Development: Serves as a key linker component in the design of proteolysis-targeting chimeras (PROTACs) and other bifunctional molecules for targeted protein degradation.
• Chemical Biology Probes: Used to create activity-based probes for studying enzyme function, protein-protein interactions, and cellular pathways.
• Pharmaceutical Intermediate: A crucial chiral intermediate in the synthetic route of potential drug candidates, particularly in oncology and neurology research.
• Material Science: Incorporation into functional polymers or hydrogels for biomedical applications such as tissue engineering scaffolds or controlled release matrices.

Basic Information

Item	Detail
Product Name	(S)-2-Azido-3-(3-indolyl)propionic acid cyclohexylammonium salt
CAS No.	1217481-78-1
Molecular Formula	C17H23N5O2
Molecular Weight	329.40 g/mol
Synonyms	(S)-2-Azido-3-(1H-indol-3-yl)propanoic acid cyclohexylamine salt; L-Azidotryptophan cyclohexylammonium salt; (S)-α-Azido-1H-indole-3-propanoic acid cyclohexylamine salt; Cyclohexylammonium (S)-2-azido-3-(1H-indol-3-yl)propanoate; Azido-DL-tryptophan cyclohexylamine salt (related); N3-Trp-OH·C6H13N; Fmoc-L-Azidotryptophan precursor salt
EINECS	Contact for details

Quality Control

We supply (S)-2-Azido-3-(3-indolyl)propionic acid cyclohexylammonium salt under strict quality protocols suitable for research and development. Our products undergo rigorous analytical testing, including HPLC for purity and chiral analysis to ensure enantiomeric excess, meeting the exacting standards required for pharmaceutical applications. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each batch to support your regulatory and research documentation.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C (refrigerated) or as indicated on the label or COA. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity. Allow the sealed container to equilibrate to room temperature before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Chiral Purity (HPLC)	≥ 98.0% ee
Water Content (KF)	≤ 2.0%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.