Description

(R)-1-(3-Chloro-5-Fluorophenyl)Ethanamine Hydrochloride is a high-purity chiral amine building block essential for advanced pharmaceutical synthesis. This compound serves as a critical intermediate in the development of active pharmaceutical ingredients (APIs), particularly for targeted therapies. It is primarily needed by research institutions and pharmaceutical manufacturers engaged in the creation of novel drugs, agrochemicals, and other fine chemicals where stereochemical purity is paramount.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of new Active Pharmaceutical Ingredients (APIs), especially for central nervous system (CNS) and oncology targets.
• Agrochemical Synthesis: Used in the production of advanced pesticides and herbicides where specific stereochemistry influences biological activity.
• Asymmetric Catalysis: Employed as a ligand precursor or chiral auxiliary in catalytic processes to induce enantioselectivity.
• Chemical Research: Serves as a valuable building block in medicinal chemistry for structure-activity relationship (SAR) studies and library synthesis.
• Process Development: Used in scaling up synthetic routes from laboratory to pilot plant and commercial manufacturing scales.

Basic Information

Product Name	(R)-1-(3-Chloro-5-Fluorophenyl)Ethanamine Hydrochloride
CAS No.	1217475-54-1
Molecular Formula	C8H10Cl2FN
Molecular Weight	210.08 g/mol
Synonyms	(R)-1-(3-Chloro-5-fluorophenyl)ethan-1-amine hydrochloride; (R)-α-Methyl-3-chloro-5-fluorobenzylamine hydrochloride; (R)-1-(3-Chloro-5-fluorophenyl)ethylamine HCl; (R)-3-Chloro-5-fluoro-α-methylbenzylamine hydrochloride; (R)-1-Aminoethyl-3-chloro-5-fluorobenzene hydrochloride; (R)-1-(3-Chloro-5-fluorophenyl)ethanamine HCl salt
EINECS	Contact for details

Quality Control

Our (R)-1-(3-Chloro-5-Fluorophenyl)Ethanamine Hydrochloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral HPLC for enantiomeric excess (ee) verification, to ensure it meets the high-purity standards required for pharmaceutical R&D. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and must be kept under dry, inert conditions to maintain stability and purity. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.