Description

(R)-1-(2,5-Difluorophenyl)Propan-1-Amine Hydrochloride is a high-purity chiral amine building block of significant importance in modern pharmaceutical research and development. Its value lies in its role as a key intermediate for synthesizing active pharmaceutical ingredients (APIs) and other fine chemicals that require a specific stereochemical configuration. This compound is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and advanced material sectors for creating novel therapeutic candidates and specialty molecules.

Application

• Pharmaceutical Intermediate: A critical chiral synthon for the synthesis of potential drug candidates, particularly in central nervous system (CNS) and metabolic disorder research.
• Agrochemical Research: Used in developing advanced, enantiomerically pure active ingredients for crop protection products.
• Asymmetric Catalysis: Serves as a precursor or ligand in catalytic systems for stereoselective chemical transformations.
• Chemical Biology & Proteomics: Employed as a building block for molecular probes and tool compounds to study biological pathways.
• Material Science: Potential use in the synthesis of chiral polymers or liquid crystals with specific optical properties.
• Custom Synthesis & Contract Manufacturing: A key starting material for custom synthesis projects requiring a defined (R)-configuration.

Basic Information

Item	Information
Product Name	(R)-1-(2,5-Difluorophenyl)Propan-1-Amine Hydrochloride
CAS No.	1217468-99-9
Molecular Formula	C9H11F2N • HCl
Molecular Weight	209.65 g/mol (Free base: 171.19 g/mol)
Synonyms	(R)-1-(2,5-Difluorophenyl)propan-1-amine hydrochloride; (R)-2,5-Difluoro-α-ethylbenzylamine hydrochloride; (R)-1-Amino-1-(2,5-difluorophenyl)propane hydrochloride; (R)-α-Ethyl-2,5-difluorobenzylamine hydrochloride; (R)-1-(2,5-Difluorophenyl)-1-propanamine hydrochloride; (R)-1-(2,5-Difluorophenyl)propylamine hydrochloride; (R)-2,5-Difluoro-α-methylphenethylamine hydrochloride (common name variant)
EINECS	Contact for details

Quality Control

Our (R)-1-(2,5-Difluorophenyl)Propan-1-Amine Hydrochloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification by HPLC, to ensure it meets the high standards required for research and development. Certificates of Analysis (COA) detailing identity, purity (typically >98.0%), enantiomeric excess (typically >99.0% ee), and impurity profiles are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); therefore, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider desiccants or an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.