Description

(2R, 3R)-3-(Boc-Amino)-2-Methyl-3-Phenylpropionic Acid CAS NO 1217456-02-4 is a high-purity, non-natural amino acid derivative featuring a tert-butoxycarbonyl (Boc) protecting group on the amine functionality. This compound is a critical chiral building block for the synthesis of complex peptides and peptidomimetics, enabling precise control over stereochemistry in advanced pharmaceutical research. It is primarily utilized by medicinal chemists and process development scientists in the pharmaceutical and biotechnology industries for drug discovery and development programs.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the research and development of novel active pharmaceutical ingredients (APIs), particularly in oncology and metabolic disease research.
• Peptide Synthesis: Serves as a protected amino acid building block in solid-phase and solution-phase peptide synthesis (SPPS) to construct peptides with specific (2R,3R) stereochemistry.
• Protease Inhibitor Development: Used in the design and synthesis of peptide-based protease inhibitors, where its stereochemistry and Boc-protected amine are crucial for binding affinity.
• Chemical Biology Probes: Incorporated into tool compounds and probes for studying enzyme function, protein-protein interactions, and cellular signaling pathways.
• Process Chemistry: Employed in the scale-up and optimization of synthetic routes for candidate drugs during late-stage development and commercial manufacturing.

Basic Information

Product Name	(2R, 3R)-3-(Boc-Amino)-2-Methyl-3-Phenylpropionic Acid
CAS No.	1217456-02-4
Molecular Formula	C16H23NO4
Molecular Weight	293.36 g/mol
Synonyms	(2R,3R)-3-[(tert-Butoxycarbonyl)amino]-2-methyl-3-phenylpropanoic acid; Boc-D-β-MePhe-OH; (2R,3R)-Boc-Amino-2-methyl-3-phenylpropionic Acid; tert-Butyl ((2R,3R)-3-carboxy-2-methyl-3-phenylpropyl)carbamate; (2R,3R)-N-Boc-2-Methyl-3-phenyl-β-alanine; Boc-(2R,3R)-β-Methylphenylalanine; (2R,3R)-3-(Boc-amino)-2-methyl-3-phenylpropanoic acid
EINECS	Contact for details

Quality Control

Our (2R, 3R)-3-(Boc-Amino)-2-Methyl-3-Phenylpropionic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral HPLC for enantiomeric excess and standard pharmacopeial identification tests, to ensure high chemical and chiral purity suitable for research and development applications. Certificates of Analysis (COA) with detailed chromatographic data are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive). For long-term storage, consider storing under an inert atmosphere to maintain optimal purity and stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.