Description

(2R,4R)-4-Amino-Pyrrolidine-2-Carboxylic Acid Dihydrochloride is a high-purity, non-proteinogenic amino acid derivative with a defined stereochemistry. This compound serves as a critical chiral building block and intermediate in advanced organic synthesis, enabling the creation of complex molecules with precise spatial orientation. It is essential for research and development in the pharmaceutical and biotechnology sectors, particularly for the synthesis of peptide-based therapeutics, enzyme inhibitors, and novel drug candidates.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the development of active pharmaceutical ingredients (APIs), especially in protease inhibitor and peptidomimetic drug discovery.
• Peptide Synthesis: Used in solid-phase and solution-phase peptide synthesis to incorporate constrained proline-like structures with an additional amino functional group.
• Biochemical Research: Employed as a substrate or inhibitor in enzymatic studies and as a building block for molecular probes and diagnostic agents.
• Asymmetric Catalysis: Acts as a precursor for chiral ligands and organocatalysts used in stereoselective chemical transformations.
• Chemical Biology: Integral for constructing modified peptides and proteins to study structure-activity relationships and biological pathways.

Basic Information

Product Name	(2R,4R)-4-Amino-Pyrrolidine-2-Carboxylic Acid Dihydrochloride
CAS No.	1217453-74-1
Molecular Formula	C5H12N2O2 • 2HCl
Molecular Weight	213.08 g/mol
Synonyms	(2R,4R)-4-Aminopyrrolidine-2-carboxylic acid dihydrochloride; (2R,4R)-4-Azanyl-2-pyrrolidinecarboxylic acid dihydrochloride; (2R,4R)-H-Pro(4-NH2)-OH•2HCl; cis-4-Amino-D-proline dihydrochloride; (2R,4R)-4-Amino-2-pyrrolidinecarboxylic acid dihydrochloride; (2R,4R)-4-Amino-2-carboxypyrrolidine dihydrochloride; (2R,4R)-4-Amino-2-pyrrolidinecarboxylic acid hydrochloride (1:2)
EINECS	Contact for details

Quality Control

Our (2R,4R)-4-Amino-Pyrrolidine-2-Carboxylic Acid Dihydrochloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification by HPLC, to ensure it meets the high standards required for pharmaceutical R&D and cGMP applications. A detailed Certificate of Analysis (COA) is provided with every shipment, confirming identity, purity, and compliance with customer specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under anhydrous conditions. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% (2R,4R) isomer
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.