Description

2-Bromo-4-Fluoro-n-Methylaniline Hydrochloride is a high-purity, halogenated aniline derivative salt, serving as a critical building block in advanced organic synthesis. Its value lies in providing a functionalized aromatic amine scaffold with bromo and fluoro substituents, enabling precise molecular modifications. This compound is primarily needed by research and development chemists in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients and complex intermediates.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for molecules targeting central nervous system (CNS) disorders and oncology.
• Agrochemical Synthesis: Used in the development of new-generation herbicides, fungicides, and pesticides, leveraging the bioactivity of halogenated anilines.
• Material Science Research: Serves as a monomer or functionalizing agent in the creation of specialty polymers and advanced organic electronic materials.
• Dye and Pigment Chemistry: Acts as a starting material for synthesizing complex, halogenated azo dyes and high-performance pigments.
• Cross-Coupling Reactions: The bromo substituent makes it an excellent substrate for palladium-catalyzed reactions like Suzuki, Heck, and Buchwald-Hartwig aminations.
• Chemical Biology Probes: Utilized in medicinal chemistry for structure-activity relationship (SAR) studies and as a tagged moiety in probe molecule development.

Basic Information

Product Name	2-Bromo-4-Fluoro-n-Methylaniline Hydrochloride
CAS No.	1216913-11-9
Molecular Formula	C7H8BrClFN
Molecular Weight	240.50 g/mol
Synonyms	2-Bromo-4-fluoro-N-methylaniline hydrochloride; 1-Bromo-2-fluoro-5-(methylamino)benzene hydrochloride; N-Methyl-2-bromo-4-fluoroaniline hydrochloride; 2-Bromo-4-fluoro-N-methylbenzenamine hydrochloride; Benzenamine, 2-bromo-4-fluoro-N-methyl-, hydrochloride; 4-Fluoro-2-bromo-N-methylaniline HCl
EINECS	Contact for details

Quality Control

Our 2-Bromo-4-Fluoro-n-Methylaniline Hydrochloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical parameters. Our quality commitment aligns with cGMP principles for pharmaceutical intermediates, ensuring reliable supply for your most demanding synthesis projects.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under dry, inert conditions to prevent degradation. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Related Substances (HPLC)	Any individual impurity ≤ 0.5%; Total impurities ≤ 1.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.