Description

4-Amino-6,8-Difluoroquinoline-3-Carboxylic Acid is a high-purity, advanced pharmaceutical intermediate with the CAS registry number 1215995-19-9. This compound is a critical building block in the synthesis of novel, potent fluoroquinolone-based active pharmaceutical ingredients (APIs). It is essential for research and development chemists and manufacturers targeting next-generation antibacterial and antimicrobial agents. Its unique difluoroquinoline scaffold offers significant potential for creating compounds with enhanced activity and improved pharmacokinetic profiles.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel fluoroquinolone antibiotics and antimicrobial agents.
• Active Pharmaceutical Ingredient (API) Development: Serves as a core scaffold for research into new antibacterial drugs with improved efficacy and safety profiles.
• Chemical Synthesis Research: Used in academic and industrial R&D for exploring new heterocyclic compounds and their biological activities.
• Process Chemistry & Scale-Up: Employed in the development and optimization of commercial-scale manufacturing routes for complex drug molecules.
• Contract Manufacturing (CMO): Supplied to contract manufacturing organizations specializing in the production of high-value pharmaceutical intermediates.
• Reference Standard: Can be utilized as a high-purity analytical standard for quality control and method development in pharmaceutical analysis.

Basic Information

Product Name	4-Amino-6,8-Difluoroquinoline-3-Carboxylic Acid
CAS No.	1215995-19-9
Molecular Formula	C₁₀H₆F₂N₂O₂
Molecular Weight	224.17 g/mol
Synonyms	6,8-Difluoro-4-aminoquinoline-3-carboxylic acid; 4-Amino-6,8-difluoroquinoline-3-carboxylic acid; 3-Quinolinecarboxylic acid, 4-amino-6,8-difluoro-; 1215995-19-9; 4-Amino-6,8-difluoro-3-quinolinecarboxylic acid; 6,8-Difluoro-4-amino-3-quinolinecarboxylic acid
EINECS	Contact for details

Quality Control

Our 4-Amino-6,8-Difluoroquinoline-3-Carboxylic Acid is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation via spectroscopic methods (NMR, IR, MS). We provide full traceability and a Certificate of Analysis (COA) with every shipment, detailing all critical quality attributes. Our production adheres to cGMP principles where applicable, ensuring consistency and reliability for your pharmaceutical development and manufacturing needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Keep away from strong acids and incompatible organic solvents. For long-term storage, consider inert atmosphere conditions to maintain optimal stability.

Specification

Item	Specification
Appearance	Off-white to light yellow crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.