Description

Quinoline, 1,2,3,4-Tetrahydro-1-(Methylsulfonyl)-7-Nitro- is a high-value, multi-functional heterocyclic compound that serves as a critical advanced intermediate in modern organic synthesis. Its unique sulfonyl and nitro-substituted tetrahydroquinoline structure makes it an essential building block for developing novel active pharmaceutical ingredients (APIs) and specialty agrochemicals. This compound is primarily sought by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and material science industries for constructing complex molecular architectures.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of novel drug candidates, particularly those targeting central nervous system (CNS) disorders, oncology, and anti-infective agents.
• Agrochemical Synthesis: Serves as a core scaffold for developing next-generation herbicides, fungicides, and insecticides with improved efficacy and selectivity.
• Material Science Research: Used in the development of organic semiconductors, light-emitting diodes (OLEDs), and advanced polymeric materials due to its electron-deficient quinoline core.
• Chemical Biology & Proteomics: Employed as a versatile building block for creating molecular probes, enzyme inhibitors, and activity-based protein profiling (ABPP) reagents.
• Catalyst & Ligand Development: The sulfonyl and nitro functional groups make it a valuable starting point for synthesizing novel chiral ligands and organocatalysts for asymmetric synthesis.
• Dye & Pigment Intermediate: Utilized in the fine chemical industry for the production of specialized dyes, pigments, and photographic chemicals.

Basic Information

Product Name	Quinoline, 1,2,3,4-Tetrahydro-1-(Methylsulfonyl)-7-Nitro-
CAS No.	1215789-23-3
Molecular Formula	C₁₀H₁₂N₂O₄S
Molecular Weight	256.28 g/mol
Synonyms	7-Nitro-1-(methylsulfonyl)-1,2,3,4-tetrahydroquinoline; 1,2,3,4-Tetrahydro-7-nitro-1-(methylsulfonyl)quinoline; 1-(Methylsulfonyl)-7-nitro-1,2,3,4-tetrahydroquinoline; 7-Nitro-1-(methanesulfonyl)-1,2,3,4-tetrahydroquinoline; 1-Methanesulfonyl-7-nitro-1,2,3,4-tetrahydroquinoline; NTQ-Sulfone; Nitro-Tetrahydroquinoline Sulfonamide Derivative
EINECS	Contact for details

Quality Control

Our products undergo rigorous quality testing to ensure compliance with industry standards for high-purity intermediates. Each batch is characterized using advanced analytical techniques including HPLC, GC-MS, and NMR to confirm identity, purity, and the absence of critical impurities. Certificates of Analysis (COA) detailing all specification parameters are available upon request. We adhere to cGMP principles where applicable to support our clients' regulatory filings.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). This material is light-sensitive and easily oxidized; for long-term storage, consider maintaining under an inert atmosphere (e.g., nitrogen or argon) to preserve stability and prevent degradation. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	Off-white to light yellow crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Single Unknown Impurity (HPLC)	≤ 1.0%
Total Impurities (HPLC)	≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.