Description

6-Bromo-2-Chloro-8-Fluoroquinoline is a high-purity, multi-halogenated quinoline derivative serving as a critical building block in advanced organic synthesis. Its unique halogen substitution pattern makes it a valuable scaffold for developing novel pharmaceutical compounds, particularly in the areas of antibacterial and anticancer research. This intermediate is essential for medicinal chemistry researchers and process development scientists in the pharmaceutical and agrochemical industries seeking to create new active molecules with targeted properties.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel fluoroquinolone antibiotics and other therapeutic agents targeting bacterial DNA gyrase and topoisomerase IV.
• Medicinal Chemistry Research: Used as a core scaffold for structure-activity relationship (SAR) studies and the development of new chemical entities in drug discovery programs.
• Agrochemical Development: Serves as a building block for creating new fungicides and herbicides, leveraging the bioactivity of the quinoline core.
• Material Science: Potential intermediate in the synthesis of organic electronic materials and ligands for catalytic systems due to its halogenated aromatic structure.
• Chemical Synthesis: Utilized in cross-coupling reactions (e.g., Suzuki, Buchwald-Hartwig) for introducing complex substituents, enabling the construction of diverse molecular libraries.

Basic Information

Product Name	6-Bromo-2-Chloro-8-Fluoroquinoline
CAS No.	1215767-81-9
Molecular Formula	C9H4BrClFN
Molecular Weight	260.49 g/mol
Synonyms	2-Chloro-6-bromo-8-fluoroquinoline; 8-Fluoro-6-bromo-2-chloroquinoline; 6-Bromo-2-chloro-8-fluoroquinoline; Quinoline, 6-bromo-2-chloro-8-fluoro-; 1215767-81-9; 6-Br-2-Cl-8-F-quinoline
EINECS	Contact for details

Quality Control

Our 6-Bromo-2-Chloro-8-Fluoroquinoline is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and residual solvent analysis. We provide a detailed Certificate of Analysis (COA) with every shipment to ensure traceability and compliance with your research and development specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). The compound should be kept under an inert atmosphere for long-term storage to maintain stability. Keep away from strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.