Description

D-Proline, 4-Methoxy-1-Methyl-, (4R)- Hydrochloride is a high-purity, non-proteinogenic amino acid derivative with a defined stereochemistry. This compound serves as a critical chiral building block and intermediate in advanced organic synthesis, enabling the creation of complex molecules with precise spatial orientation. It is primarily required by pharmaceutical research and development teams, agrochemical innovators, and specialty chemical manufacturers for applications in drug discovery, asymmetric catalysis, and the synthesis of bioactive compounds.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of novel active pharmaceutical ingredients (APIs), particularly for central nervous system (CNS) and metabolic disorder targets.
• Asymmetric Catalysis: Used as a precursor or ligand component in the development of chiral catalysts for stereoselective synthesis.
• Peptidomimetics & Drug Design: Incorporated into peptide analogs and peptidomimetic structures to enhance metabolic stability, bioavailability, and receptor selectivity.
• Agrochemical Research: Serves as a building block for the synthesis of chiral herbicides, fungicides, and plant growth regulators.
• Biochemical Research: Utilized in enzymatic studies and as a substrate or inhibitor for proline-specific enzymes.
• Material Science: Potential monomer or additive in the synthesis of specialized polymers and functional materials.

Basic Information

Product Name	D-Proline, 4-Methoxy-1-Methyl-, (4R)- Hydrochloride
CAS No.	1215385-33-3
Molecular Formula	C7H14ClNO3 (or C7H13NO3 · HCl)
Molecular Weight	195.65 g/mol (Free base: 159.18 g/mol)
Synonyms	(4R)-4-Methoxy-1-methyl-D-proline hydrochloride; (4R)-1-Methyl-4-methoxy-D-proline hydrochloride; D-1-Methyl-4-methoxyproline hydrochloride; (R)-1-Methyl-4-methoxypyrrolidine-2-carboxylic acid hydrochloride; 4-Methoxy-1-methyl-L-proline hydrochloride (enantiomer); 4-Methoxy-N-methyl-D-proline HCl; (2R,4R)-1-Methyl-4-methoxypyrrolidine-2-carboxylic acid hydrochloride
EINECS	Contact for details

Quality Control

Our D-Proline, 4-Methoxy-1-Methyl-, (4R)- Hydrochloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification by HPLC, to ensure it meets the high standards required for research and development. A detailed Certificate of Analysis (COA) providing batch-specific data for identity, purity, and chiral excess is available for every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under anhydrous conditions. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.